HOXA10 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HOXA10

Homeobox A10. (94 aa)

Predicted Functional Partners:

HOXA9

0.895

HOXA7

0.657

OTUD4

0.591

PGR

0.558

LCOR

0.542

MEIS1

0.524

ESR1

0.520

IPO7

0.514

IPO8

0.514

HOXD10

0.481

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	HOXA10	ENSCAFP00000000624	ENSCAFP00000004395	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Homeobox A10.	0.520
ESR1	PGR	ENSCAFP00000000624	ENSCAFP00000005906	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.948
HOXA10	ESR1	ENSCAFP00000004395	ENSCAFP00000000624	Homeobox A10.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.520
HOXA10	HOXA7	ENSCAFP00000004395	ENSCAFP00000004385	Homeobox A10.	Homeobox A7.	0.657
HOXA10	HOXA9	ENSCAFP00000004395	ENSCAFP00000004393	Homeobox A10.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.895
HOXA10	HOXD10	ENSCAFP00000004395	ENSCAFP00000019805	Homeobox A10.	Homeobox D10.	0.481
HOXA10	IPO7	ENSCAFP00000004395	ENSCAFP00000010873	Homeobox A10.	Importin 7.	0.514
HOXA10	IPO8	ENSCAFP00000004395	ENSCAFP00000015868	Homeobox A10.	Importin 8.	0.514
HOXA10	LCOR	ENSCAFP00000004395	ENSCAFP00000041658	Homeobox A10.	Ligand dependent nuclear receptor corepressor.	0.542
HOXA10	MEIS1	ENSCAFP00000004395	ENSCAFP00000050012	Homeobox A10.	Meis homeobox 1.	0.524
HOXA10	OTUD4	ENSCAFP00000004395	ENSCAFP00000046530	Homeobox A10.	OTU deubiquitinase 4.	0.591
HOXA10	PGR	ENSCAFP00000004395	ENSCAFP00000005906	Homeobox A10.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily.	0.558
HOXA7	HOXA10	ENSCAFP00000004385	ENSCAFP00000004395	Homeobox A7.	Homeobox A10.	0.657
HOXA7	HOXA9	ENSCAFP00000004385	ENSCAFP00000004393	Homeobox A7.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.755
HOXA9	HOXA10	ENSCAFP00000004393	ENSCAFP00000004395	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox A10.	0.895
HOXA9	HOXA7	ENSCAFP00000004393	ENSCAFP00000004385	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox A7.	0.755
HOXA9	HOXD10	ENSCAFP00000004393	ENSCAFP00000019805	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox D10.	0.920
HOXA9	MEIS1	ENSCAFP00000004393	ENSCAFP00000050012	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Meis homeobox 1.	0.870
HOXD10	HOXA10	ENSCAFP00000019805	ENSCAFP00000004395	Homeobox D10.	Homeobox A10.	0.481
HOXD10	HOXA9	ENSCAFP00000019805	ENSCAFP00000004393	Homeobox D10.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.920