Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RLFRearranged L-myc fusion. (1911 aa)    
Predicted Functional Partners:
RXFP3
Relaxin family peptide receptor 3.
    
 
 0.815
RLN3
Relaxin 3.
      
 0.810
PARG
Poly(ADP-ribose) glycohydrolase.
   
   0.641
RXFP1
Relaxin family peptide receptor 1.
    
 0.632
COLCA2
Uncharacterized protein.
      
 0.615
WBP1L
WW domain binding protein 1 like.
      
 0.611
C31H21orf91
Chromosome 31 C21orf91 homolog.
      
 0.589
RXFP2
Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family.
    
 0.559
KLHL7
Kelch like family member 7.
    
 
 0.552
MYCL
MYCL proto-oncogene, bHLH transcription factor.
    
 0.539
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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