NOD1 protein (Canis lupus familiaris) - STRING interaction network

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Score

NOD1

Nucleotide binding oligomerization domain containing 1. (964 aa)

Predicted Functional Partners:

RIPK2

0.990

ATG16L1

0.977

SUGT1

0.937

NOD2

0.926

CASP4

0.846

TLR2

0.821

MEFV

0.818

TRAF6

0.739

TLR5

0.732

TAB1

0.712

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG16L1	MEFV	ENSCAFP00000052433	ENSCAFP00000033373	Autophagy related 16 like 1.	MEFV innate immuity regulator, pyrin.	0.417
ATG16L1	NOD1	ENSCAFP00000052433	ENSCAFP00000004572	Autophagy related 16 like 1.	Nucleotide binding oligomerization domain containing 1.	0.977
ATG16L1	NOD2	ENSCAFP00000052433	ENSCAFP00000014425	Autophagy related 16 like 1.	Uncharacterized protein.	0.994
ATG16L1	RIPK2	ENSCAFP00000052433	ENSCAFP00000013170	Autophagy related 16 like 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.437
CASP4	MEFV	ENSCAFP00000031566	ENSCAFP00000033373	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	MEFV innate immuity regulator, pyrin.	0.912
CASP4	NOD1	ENSCAFP00000031566	ENSCAFP00000004572	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Nucleotide binding oligomerization domain containing 1.	0.846
CASP4	NOD2	ENSCAFP00000031566	ENSCAFP00000014425	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein.	0.761
CASP4	RIPK2	ENSCAFP00000031566	ENSCAFP00000013170	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.426
CASP4	TLR2	ENSCAFP00000031566	ENSCAFP00000012269	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.787
CASP4	TLR5	ENSCAFP00000031566	ENSCAFP00000016726	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.560
CASP4	TRAF6	ENSCAFP00000031566	ENSCAFP00000010159	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.493
MEFV	ATG16L1	ENSCAFP00000033373	ENSCAFP00000052433	MEFV innate immuity regulator, pyrin.	Autophagy related 16 like 1.	0.417
MEFV	CASP4	ENSCAFP00000033373	ENSCAFP00000031566	MEFV innate immuity regulator, pyrin.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.912
MEFV	NOD1	ENSCAFP00000033373	ENSCAFP00000004572	MEFV innate immuity regulator, pyrin.	Nucleotide binding oligomerization domain containing 1.	0.818
MEFV	NOD2	ENSCAFP00000033373	ENSCAFP00000014425	MEFV innate immuity regulator, pyrin.	Uncharacterized protein.	0.726
NOD1	ATG16L1	ENSCAFP00000004572	ENSCAFP00000052433	Nucleotide binding oligomerization domain containing 1.	Autophagy related 16 like 1.	0.977
NOD1	CASP4	ENSCAFP00000004572	ENSCAFP00000031566	Nucleotide binding oligomerization domain containing 1.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.846
NOD1	MEFV	ENSCAFP00000004572	ENSCAFP00000033373	Nucleotide binding oligomerization domain containing 1.	MEFV innate immuity regulator, pyrin.	0.818
NOD1	NOD2	ENSCAFP00000004572	ENSCAFP00000014425	Nucleotide binding oligomerization domain containing 1.	Uncharacterized protein.	0.926
NOD1	RIPK2	ENSCAFP00000004572	ENSCAFP00000013170	Nucleotide binding oligomerization domain containing 1.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.990