ORC3 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

ORC3

Origin recognition complex subunit 3. (773 aa)

Predicted Functional Partners:

ORC5

0.999

ORC2

0.999

ORC1

0.999

ORC4

0.999

ORC6

0.999

LRWD1

0.996

CDC6

0.991

CDC45

0.990

MCM7

0.989

CDT1

0.988

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC45	CDC6	ENSCAFP00000021510	ENSCAFP00000023734	Cell division cycle 45.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.938
CDC45	CDT1	ENSCAFP00000021510	ENSCAFP00000029426	Cell division cycle 45.	Chromatin licensing and DNA replication factor 1.	0.989
CDC45	MCM7	ENSCAFP00000021510	ENSCAFP00000021778	Cell division cycle 45.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.997
CDC45	ORC1	ENSCAFP00000021510	ENSCAFP00000046312	Cell division cycle 45.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.981
CDC45	ORC2	ENSCAFP00000021510	ENSCAFP00000044438	Cell division cycle 45.	Origin recognition complex subunit 2.	0.954
CDC45	ORC3	ENSCAFP00000021510	ENSCAFP00000004584	Cell division cycle 45.	Origin recognition complex subunit 3.	0.990
CDC45	ORC4	ENSCAFP00000021510	ENSCAFP00000065088	Cell division cycle 45.	Origin recognition complex subunit 4.	0.870
CDC45	ORC5	ENSCAFP00000021510	ENSCAFP00000006164	Cell division cycle 45.	Origin recognition complex subunit 5.	0.984
CDC45	ORC6	ENSCAFP00000021510	ENSCAFP00000065653	Cell division cycle 45.	Origin recognition complex subunit 6.	0.949
CDC6	CDC45	ENSCAFP00000023734	ENSCAFP00000021510	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Cell division cycle 45.	0.938
CDC6	CDT1	ENSCAFP00000023734	ENSCAFP00000029426	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Chromatin licensing and DNA replication factor 1.	0.999
CDC6	MCM7	ENSCAFP00000023734	ENSCAFP00000021778	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.994
CDC6	ORC1	ENSCAFP00000023734	ENSCAFP00000046312	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.997
CDC6	ORC2	ENSCAFP00000023734	ENSCAFP00000044438	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 2.	0.984
CDC6	ORC3	ENSCAFP00000023734	ENSCAFP00000004584	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 3.	0.991
CDC6	ORC4	ENSCAFP00000023734	ENSCAFP00000065088	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 4.	0.979
CDC6	ORC5	ENSCAFP00000023734	ENSCAFP00000006164	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 5.	0.983
CDC6	ORC6	ENSCAFP00000023734	ENSCAFP00000065653	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	Origin recognition complex subunit 6.	0.973
CDT1	CDC45	ENSCAFP00000029426	ENSCAFP00000021510	Chromatin licensing and DNA replication factor 1.	Cell division cycle 45.	0.989
CDT1	CDC6	ENSCAFP00000029426	ENSCAFP00000023734	Chromatin licensing and DNA replication factor 1.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.999