Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)    
Predicted Functional Partners:
IRAK4
Interleukin 1 receptor associated kinase 4.
    
 0.986
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.986
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.950
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.927
RIPK3
Protein kinase domain-containing protein.
    
 0.846
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.713
MDM4
MDM4 regulator of p53.
   
 
 0.690
UBE2N-3
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.670
TBK1
TANK binding kinase 1.
   
 
 0.670
PELI3
E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
    
   0.632
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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