STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)    
Predicted Functional Partners:
IRAK1
Interleukin 1 receptor associated kinase 1.
    
 0.936
IRAK4
Interleukin 1 receptor associated kinase 4.
   
 0.896
RIPK1
Receptor interacting serine/threonine kinase 1.
    
 0.871
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.861
RIPK3
Protein kinase domain-containing protein.
    
 0.847
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.614
UBE2V1
Ubiquitin conjugating enzyme E2 V1.
    
 0.593
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 0.575
RNF138
Ring finger protein 138.
   
  
 0.567
UBE2N-2
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.564
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.