STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYRENCell cycle regulator of NHEJ. (147 aa)    
Predicted Functional Partners:
ERCC6L2
ERCC excision repair 6 like 2.
    
 
 0.628
PAXX
PAXX non-homologous end joining factor.
      
 0.564
APLF
Aprataxin and PNKP like factor.
      
 0.499
SHLD1
Shieldin complex subunit 1.
      
 0.499
NHEJ1
Non-homologous end joining factor 1.
      
 0.497
UBIAD1
UbiA prenyltransferase domain containing 1.
      
 0.495
HMCES
Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]
      
 0.493
AUNIP
Aurora kinase A and ninein interacting protein.
      
 0.489
LYRM1
LYR motif containing 1; Belongs to the complex I LYR family.
      
 0.480
SLC25A32
Solute carrier family 25 member 32; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.470
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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