CYREN protein (Canis lupus familiaris) - STRING interaction network

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CYREN

Cell cycle regulator of NHEJ. (147 aa)

Predicted Functional Partners:

PAXX

0.918

ERCC6L2

0.745

PRKDC

0.693

XKR4

0.643

ATM

0.623

APLF

0.615

LIG4

0.592

MRI1

0.589

NHEJ1

0.587

FOXRED1

0.573

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	ATM	ENSCAFP00000004843	ENSCAFP00000035996	Aprataxin and PNKP like factor.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.409
APLF	CYREN	ENSCAFP00000004843	ENSCAFP00000004743	Aprataxin and PNKP like factor.	Cell cycle regulator of NHEJ.	0.615
APLF	LIG4	ENSCAFP00000004843	ENSCAFP00000009027	Aprataxin and PNKP like factor.	DNA ligase.	0.969
APLF	NHEJ1	ENSCAFP00000004843	ENSCAFP00000039487	Aprataxin and PNKP like factor.	Non-homologous end joining factor 1.	0.449
APLF	PAXX	ENSCAFP00000004843	ENSCAFP00000063932	Aprataxin and PNKP like factor.	PAXX non-homologous end joining factor.	0.821
APLF	PRKDC	ENSCAFP00000004843	ENSCAFP00000009842	Aprataxin and PNKP like factor.	DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...]	0.650
APLF	XKR4	ENSCAFP00000004843	ENSCAFP00000010384	Aprataxin and PNKP like factor.	XK-related protein.	0.684
ATM	APLF	ENSCAFP00000035996	ENSCAFP00000004843	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Aprataxin and PNKP like factor.	0.409
ATM	CYREN	ENSCAFP00000035996	ENSCAFP00000004743	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell cycle regulator of NHEJ.	0.623
ATM	LIG4	ENSCAFP00000035996	ENSCAFP00000009027	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA ligase.	0.899
ATM	NHEJ1	ENSCAFP00000035996	ENSCAFP00000039487	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-homologous end joining factor 1.	0.784
ATM	PAXX	ENSCAFP00000035996	ENSCAFP00000063932	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAXX non-homologous end joining factor.	0.586
ATM	PRKDC	ENSCAFP00000035996	ENSCAFP00000009842	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...]	0.885
CYREN	APLF	ENSCAFP00000004743	ENSCAFP00000004843	Cell cycle regulator of NHEJ.	Aprataxin and PNKP like factor.	0.615
CYREN	ATM	ENSCAFP00000004743	ENSCAFP00000035996	Cell cycle regulator of NHEJ.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.623
CYREN	ERCC6L2	ENSCAFP00000004743	ENSCAFP00000001757	Cell cycle regulator of NHEJ.	ERCC excision repair 6 like 2.	0.745
CYREN	FOXRED1	ENSCAFP00000004743	ENSCAFP00000015364	Cell cycle regulator of NHEJ.	FAD dependent oxidoreductase domain containing 1.	0.573
CYREN	LIG4	ENSCAFP00000004743	ENSCAFP00000009027	Cell cycle regulator of NHEJ.	DNA ligase.	0.592
CYREN	MRI1	ENSCAFP00000004743	ENSCAFP00000024457	Cell cycle regulator of NHEJ.	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.	0.589
CYREN	NHEJ1	ENSCAFP00000004743	ENSCAFP00000039487	Cell cycle regulator of NHEJ.	Non-homologous end joining factor 1.	0.587