ETAA1 protein (Canis lupus familiaris) - STRING interaction network

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Score

ETAA1

ETAA1 activator of ATR kinase. (857 aa)

Predicted Functional Partners:

ATRIP

0.872

RPA1

0.860

ATR

0.822

RPA2

0.784

TOPBP1

0.763

BRCA1

0.761

KIAA2026

0.716

PIK3IP1

0.698

ZSWIM2

0.674

RMI1

0.649

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATR	ATRIP	ENSCAFP00000011639	ENSCAFP00000018463	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ATR interacting protein.	0.999
ATR	BRCA1	ENSCAFP00000011639	ENSCAFP00000048759	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.995
ATR	ETAA1	ENSCAFP00000011639	ENSCAFP00000004806	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	ETAA1 activator of ATR kinase.	0.822
ATR	RPA1	ENSCAFP00000011639	ENSCAFP00000028391	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.879
ATR	RPA2	ENSCAFP00000011639	ENSCAFP00000061592	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Replication protein A2.	0.807
ATR	TOPBP1	ENSCAFP00000011639	ENSCAFP00000009662	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	DNA topoisomerase II binding protein 1.	0.984
ATRIP	ATR	ENSCAFP00000018463	ENSCAFP00000011639	ATR interacting protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.999
ATRIP	BRCA1	ENSCAFP00000018463	ENSCAFP00000048759	ATR interacting protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.935
ATRIP	ETAA1	ENSCAFP00000018463	ENSCAFP00000004806	ATR interacting protein.	ETAA1 activator of ATR kinase.	0.872
ATRIP	RMI1	ENSCAFP00000018463	ENSCAFP00000001985	ATR interacting protein.	RecQ mediated genome instability 1.	0.548
ATRIP	RPA1	ENSCAFP00000018463	ENSCAFP00000028391	ATR interacting protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.963
ATRIP	RPA2	ENSCAFP00000018463	ENSCAFP00000061592	ATR interacting protein.	Replication protein A2.	0.805
ATRIP	TOPBP1	ENSCAFP00000018463	ENSCAFP00000009662	ATR interacting protein.	DNA topoisomerase II binding protein 1.	0.985
BRCA1	ATR	ENSCAFP00000048759	ENSCAFP00000011639	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.995
BRCA1	ATRIP	ENSCAFP00000048759	ENSCAFP00000018463	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ATR interacting protein.	0.935
BRCA1	ETAA1	ENSCAFP00000048759	ENSCAFP00000004806	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	ETAA1 activator of ATR kinase.	0.761
BRCA1	RMI1	ENSCAFP00000048759	ENSCAFP00000001985	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RecQ mediated genome instability 1.	0.715
BRCA1	RPA1	ENSCAFP00000048759	ENSCAFP00000028391	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.912
BRCA1	RPA2	ENSCAFP00000048759	ENSCAFP00000061592	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Replication protein A2.	0.429
BRCA1	TOPBP1	ENSCAFP00000048759	ENSCAFP00000009662	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA topoisomerase II binding protein 1.	0.988