APLF protein (Canis lupus familiaris) - STRING interaction network

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Score

APLF

Aprataxin and PNKP like factor. (510 aa)

Predicted Functional Partners:

XRCC5

0.948

XRCC6

0.928

XRCC1

0.879

PARP3

0.873

APTX

0.868

KRT222

0.855

LIG4

0.787

PARP1

0.787

NEIL2

0.785

ZBTB24

0.775

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	APTX	ENSCAFP00000004843	ENSCAFP00000051773	Aprataxin and PNKP like factor.	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	0.868
APLF	KRT222	ENSCAFP00000004843	ENSCAFP00000036034	Aprataxin and PNKP like factor.	IF rod domain-containing protein; Belongs to the intermediate filament family.	0.855
APLF	LIG4	ENSCAFP00000004843	ENSCAFP00000009027	Aprataxin and PNKP like factor.	DNA ligase.	0.787
APLF	NEIL2	ENSCAFP00000004843	ENSCAFP00000011772	Aprataxin and PNKP like factor.	Nei like DNA glycosylase 2.	0.785
APLF	PARP1	ENSCAFP00000004843	ENSCAFP00000023715	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.787
APLF	PARP3	ENSCAFP00000004843	ENSCAFP00000014771	Aprataxin and PNKP like factor.	Poly [ADP-ribose] polymerase.	0.873
APLF	XRCC1	ENSCAFP00000004843	ENSCAFP00000064180	Aprataxin and PNKP like factor.	Uncharacterized protein.	0.879
APLF	XRCC5	ENSCAFP00000004843	ENSCAFP00000038467	Aprataxin and PNKP like factor.	X-ray repair cross complementing 5.	0.948
APLF	XRCC6	ENSCAFP00000004843	ENSCAFP00000058107	Aprataxin and PNKP like factor.	X-ray repair cross complementing 6.	0.928
APLF	ZBTB24	ENSCAFP00000004843	ENSCAFP00000005701	Aprataxin and PNKP like factor.	Zinc finger and BTB domain containing 24.	0.775
APTX	APLF	ENSCAFP00000051773	ENSCAFP00000004843	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	Aprataxin and PNKP like factor.	0.868
APTX	LIG4	ENSCAFP00000051773	ENSCAFP00000009027	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	DNA ligase.	0.622
APTX	PARP1	ENSCAFP00000051773	ENSCAFP00000023715	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.624
APTX	XRCC1	ENSCAFP00000051773	ENSCAFP00000064180	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	Uncharacterized protein.	0.864
APTX	XRCC5	ENSCAFP00000051773	ENSCAFP00000038467	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	X-ray repair cross complementing 5.	0.460
APTX	XRCC6	ENSCAFP00000051773	ENSCAFP00000058107	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	X-ray repair cross complementing 6.	0.479
KRT222	APLF	ENSCAFP00000036034	ENSCAFP00000004843	IF rod domain-containing protein; Belongs to the intermediate filament family.	Aprataxin and PNKP like factor.	0.855
LIG4	APLF	ENSCAFP00000009027	ENSCAFP00000004843	DNA ligase.	Aprataxin and PNKP like factor.	0.787
LIG4	APTX	ENSCAFP00000009027	ENSCAFP00000051773	DNA ligase.	Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP- NH(2)) and diadenosine tetraphosphate (AppppA), b [...]	0.622
LIG4	PARP1	ENSCAFP00000009027	ENSCAFP00000023715	DNA ligase.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.449