STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANXA4Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. (645 aa)    
Predicted Functional Partners:
ENSCAFP00000050810
Uncharacterized protein.
 
 
 
 0.646
HSPA4
Heat shock 70 kDa protein 4.
   
  
 0.629
CD63
Tetraspanin.
   
  
 0.585
GNB2
G protein subunit beta 2.
   
  
 0.580
ASCC1
Activating signal cointegrator 1 complex subunit 1.
   
  
 0.562
CD9
Tetraspanin.
   
 
 0.551
TUBA4A
Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
   
  
 0.534
GNB4
G protein subunit beta 4.
   
  
 0.532
PLG
Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...]
    
 
 0.516
LAMP1
Lysosomal associated membrane protein 1.
   
  
 0.513
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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