STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASPRV1Aspartic peptidase retroviral like 1. (319 aa)    
Predicted Functional Partners:
NIPAL4
NIPA like domain containing 4.
      
 0.866
PNPLA1
PNPLA domain-containing protein.
   
  
 0.854
TGM1
Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity); Belongs to the transglutaminase superfamily. Transglutaminase family.
   
  
 0.835
SLC27A4
Solute carrier family 27 member 4.
      
 0.818
ABHD5
Abhydrolase domain containing 5.
      
 0.690
CASP14
Caspase 14; Belongs to the peptidase C14A family.
   
  
 0.660
KRT10
Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin; Belongs to the intermediate filament family.
   
  
 0.643
FAM25A
Uncharacterized protein.
   
  
 0.602
CCDC8
Coiled-coil domain containing 8.
      
 0.566
TSPAN18
Tetraspanin.
      
 0.524
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.