ABCA4 protein (Canis lupus familiaris) - STRING interaction network

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Score

ABCA4

ATP binding cassette subfamily A member 4. (2321 aa)

Predicted Functional Partners:

APOA1

0.892

RPE65

0.856

USH2A

0.823

MYO7A

0.816

EYS-2

0.811

EYS

0.810

CNGB3

0.802

CEP290

0.797

PRPH2

0.782

ELOVL4

0.771

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA4	APOA1	ENSCAFP00000004971	ENSCAFP00000019630	ATP binding cassette subfamily A member 4.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.892
ABCA4	CEP290	ENSCAFP00000004971	ENSCAFP00000054723	ATP binding cassette subfamily A member 4.	Centrosomal protein 290.	0.797
ABCA4	CNGB3	ENSCAFP00000004971	ENSCAFP00000013075	ATP binding cassette subfamily A member 4.	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	0.802
ABCA4	ELOVL4	ENSCAFP00000004971	ENSCAFP00000043098	ATP binding cassette subfamily A member 4.	Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...]	0.771
ABCA4	EYS	ENSCAFP00000004971	ENSCAFP00000003634	ATP binding cassette subfamily A member 4.	Uncharacterized protein.	0.810
ABCA4	EYS-2	ENSCAFP00000004971	ENSCAFP00000052143	ATP binding cassette subfamily A member 4.	Uncharacterized protein.	0.811
ABCA4	MYO7A	ENSCAFP00000004971	ENSCAFP00000007700	ATP binding cassette subfamily A member 4.	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.816
ABCA4	PRPH2	ENSCAFP00000004971	ENSCAFP00000002506	ATP binding cassette subfamily A member 4.	Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family.	0.782
ABCA4	RPE65	ENSCAFP00000004971	ENSCAFP00000030301	ATP binding cassette subfamily A member 4.	Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...]	0.856
ABCA4	USH2A	ENSCAFP00000004971	ENSCAFP00000015796	ATP binding cassette subfamily A member 4.	Usherin.	0.823
APOA1	ABCA4	ENSCAFP00000019630	ENSCAFP00000004971	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	ATP binding cassette subfamily A member 4.	0.892
CEP290	ABCA4	ENSCAFP00000054723	ENSCAFP00000004971	Centrosomal protein 290.	ATP binding cassette subfamily A member 4.	0.797
CEP290	CNGB3	ENSCAFP00000054723	ENSCAFP00000013075	Centrosomal protein 290.	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	0.537
CEP290	EYS	ENSCAFP00000054723	ENSCAFP00000003634	Centrosomal protein 290.	Uncharacterized protein.	0.528
CEP290	EYS-2	ENSCAFP00000054723	ENSCAFP00000052143	Centrosomal protein 290.	Uncharacterized protein.	0.529
CEP290	MYO7A	ENSCAFP00000054723	ENSCAFP00000007700	Centrosomal protein 290.	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.596
CEP290	PRPH2	ENSCAFP00000054723	ENSCAFP00000002506	Centrosomal protein 290.	Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity). Belongs to the PRPH2/ROM1 family.	0.597
CEP290	RPE65	ENSCAFP00000054723	ENSCAFP00000030301	Centrosomal protein 290.	Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...]	0.851
CEP290	USH2A	ENSCAFP00000054723	ENSCAFP00000015796	Centrosomal protein 290.	Usherin.	0.770
CNGB3	ABCA4	ENSCAFP00000013075	ENSCAFP00000004971	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	ATP binding cassette subfamily A member 4.	0.802