STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
STK40Serine/threonine kinase 40. (470 aa)    
Predicted Functional Partners:
TRIB3
Tribbles pseudokinase 3.
    
 
 0.932
TRIB1
Protein kinase domain-containing protein.
    
 
 0.927
COP1
COP1 E3 ubiquitin ligase.
    
 
 0.927
ETV1
ETS variant 1.
    
   0.926
FOSL2
FOS like 2, AP-1 transcription factor subunit.
   
 
 0.856
TRIB2
Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.
    
 
 0.838
JUNB
JunB proto-oncogene, AP-1 transcription factor subunit.
    
 
 0.825
DNAJB4
DnaJ heat shock protein family (Hsp40) member B4.
   
 
 0.816
DET1
DET1 partner of COP1 E3 ubiquitin ligase.
    
 
 0.799
YARS1
Tyrosine--tRNA ligase.
      
 0.792
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.