GRB10 protein (Canis lupus familiaris) - STRING interaction network

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Score

GRB10

Growth factor receptor bound protein 10. (546 aa)

Predicted Functional Partners:

NEDD4

0.914

PIK3R1

0.885

INSR

0.879

IGF1R

0.839

PIK3CA

0.808

PLAG1

0.770

GIGYF2

0.755

CDKN1B

0.737

INS

0.732

GPC3

0.728

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN1B	GPC3	ENSCAFP00000019502	ENSCAFP00000027825	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.795
CDKN1B	GRB10	ENSCAFP00000019502	ENSCAFP00000005101	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	Growth factor receptor bound protein 10.	0.737
CDKN1B	IGF1R	ENSCAFP00000019502	ENSCAFP00000043796	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	Tyrosine-protein kinase receptor.	0.404
CDKN1B	PLAG1	ENSCAFP00000019502	ENSCAFP00000010477	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	PLAG1 zinc finger.	0.770
GIGYF2	GRB10	ENSCAFP00000016998	ENSCAFP00000005101	GRB10 interacting GYF protein 2.	Growth factor receptor bound protein 10.	0.755
GPC3	CDKN1B	ENSCAFP00000027825	ENSCAFP00000019502	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.795
GPC3	GRB10	ENSCAFP00000027825	ENSCAFP00000005101	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Growth factor receptor bound protein 10.	0.728
GPC3	IGF1R	ENSCAFP00000027825	ENSCAFP00000043796	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Tyrosine-protein kinase receptor.	0.516
GPC3	PLAG1	ENSCAFP00000027825	ENSCAFP00000010477	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	PLAG1 zinc finger.	0.764
GRB10	CDKN1B	ENSCAFP00000005101	ENSCAFP00000019502	Growth factor receptor bound protein 10.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.737
GRB10	GIGYF2	ENSCAFP00000005101	ENSCAFP00000016998	Growth factor receptor bound protein 10.	GRB10 interacting GYF protein 2.	0.755
GRB10	GPC3	ENSCAFP00000005101	ENSCAFP00000027825	Growth factor receptor bound protein 10.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.728
GRB10	IGF1R	ENSCAFP00000005101	ENSCAFP00000043796	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.839
GRB10	INS	ENSCAFP00000005101	ENSCAFP00000051648	Growth factor receptor bound protein 10.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.732
GRB10	INSR	ENSCAFP00000005101	ENSCAFP00000038176	Growth factor receptor bound protein 10.	Tyrosine-protein kinase receptor.	0.879
GRB10	NEDD4	ENSCAFP00000005101	ENSCAFP00000023564	Growth factor receptor bound protein 10.	NEDD4 E3 ubiquitin protein ligase.	0.914
GRB10	PIK3CA	ENSCAFP00000005101	ENSCAFP00000048355	Growth factor receptor bound protein 10.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.808
GRB10	PIK3R1	ENSCAFP00000005101	ENSCAFP00000011322	Growth factor receptor bound protein 10.	Phosphoinositide-3-kinase regulatory subunit 1.	0.885
GRB10	PLAG1	ENSCAFP00000005101	ENSCAFP00000010477	Growth factor receptor bound protein 10.	PLAG1 zinc finger.	0.770
IGF1R	CDKN1B	ENSCAFP00000043796	ENSCAFP00000019502	Tyrosine-protein kinase receptor.	Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.	0.404