STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CUL1Cullin 1; Belongs to the cullin family. (776 aa)    
Predicted Functional Partners:
SKP1
S-phase kinase associated protein 1; Belongs to the SKP1 family.
   
 0.999
SKP2
S-phase kinase associated protein 2.
   
 0.999
RBX1
Ring-box 1.
    
 0.999
BTRC
Beta-transducin repeat containing E3 ubiquitin protein ligase.
   
 0.997
FBXW11
F-box and WD repeat domain containing 11.
   
 0.995
NEDD8
NEDD8 ubiquitin like modifier.
    
 0.993
CAND1
Cullin associated and neddylation dissociated 1.
   
 0.989
UBE2M
Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.989
CDKN1B
Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
    
 0.976
CKS1B
Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
   
 0.968
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.