PAPPA protein (Canis lupus familiaris) - STRING interaction network

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Score

PAPPA

Pappalysin 1. (1488 aa)

Predicted Functional Partners:

IGFBP5

0.857

STC2

0.837

IGFBP4

0.808

PRG3

0.760

ENSCAFP00000053091

0.760

IGF1

0.705

ANP32E

0.700

ANP32A

0.700

IGF2

0.566

TSHR

0.552

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANP32A	PAPPA	ENSCAFP00000025783	ENSCAFP00000005199	Acidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression (By similarity).	Pappalysin 1.	0.700
ANP32E	PAPPA	ENSCAFP00000017286	ENSCAFP00000005199	Acidic nuclear phosphoprotein 32 family member E.	Pappalysin 1.	0.700
ENSCAFP00000053091	PAPPA	ENSCAFP00000053091	ENSCAFP00000005199	C-type lectin domain-containing protein.	Pappalysin 1.	0.760
IGF1	IGF2	ENSCAFP00000058639	ENSCAFP00000063478	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor 2.	0.973
IGF1	IGFBP4	ENSCAFP00000058639	ENSCAFP00000023677	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 4.	0.993
IGF1	IGFBP5	ENSCAFP00000058639	ENSCAFP00000021360	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 5.	0.955
IGF1	PAPPA	ENSCAFP00000058639	ENSCAFP00000005199	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Pappalysin 1.	0.705
IGF2	IGF1	ENSCAFP00000063478	ENSCAFP00000058639	Insulin like growth factor 2.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.973
IGF2	IGFBP4	ENSCAFP00000063478	ENSCAFP00000023677	Insulin like growth factor 2.	Insulin like growth factor binding protein 4.	0.990
IGF2	IGFBP5	ENSCAFP00000063478	ENSCAFP00000021360	Insulin like growth factor 2.	Insulin like growth factor binding protein 5.	0.887
IGF2	PAPPA	ENSCAFP00000063478	ENSCAFP00000005199	Insulin like growth factor 2.	Pappalysin 1.	0.566
IGFBP4	IGF1	ENSCAFP00000023677	ENSCAFP00000058639	Insulin like growth factor binding protein 4.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.993
IGFBP4	IGF2	ENSCAFP00000023677	ENSCAFP00000063478	Insulin like growth factor binding protein 4.	Insulin like growth factor 2.	0.990
IGFBP4	PAPPA	ENSCAFP00000023677	ENSCAFP00000005199	Insulin like growth factor binding protein 4.	Pappalysin 1.	0.808
IGFBP5	IGF1	ENSCAFP00000021360	ENSCAFP00000058639	Insulin like growth factor binding protein 5.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.955
IGFBP5	IGF2	ENSCAFP00000021360	ENSCAFP00000063478	Insulin like growth factor binding protein 5.	Insulin like growth factor 2.	0.887
IGFBP5	PAPPA	ENSCAFP00000021360	ENSCAFP00000005199	Insulin like growth factor binding protein 5.	Pappalysin 1.	0.857
PAPPA	ANP32A	ENSCAFP00000005199	ENSCAFP00000025783	Pappalysin 1.	Acidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression (By similarity).	0.700
PAPPA	ANP32E	ENSCAFP00000005199	ENSCAFP00000017286	Pappalysin 1.	Acidic nuclear phosphoprotein 32 family member E.	0.700
PAPPA	ENSCAFP00000053091	ENSCAFP00000005199	ENSCAFP00000053091	Pappalysin 1.	C-type lectin domain-containing protein.	0.760