PAPPA protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

PAPPA

Pappalysin 1. (1488 aa)

Predicted Functional Partners:

IGFBP5

0.854

STC2

0.780

PRG3

0.689

ENSCAFP00000053091

0.688

IGFBP4

0.672

IGF2

0.668

IGF1

0.665

TSHR

0.612

IL16

0.562

IGFBP2

0.537

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000053091	PAPPA	ENSCAFP00000053091	ENSCAFP00000005199	C-type lectin domain-containing protein.	Pappalysin 1.	0.688
IGF1	IGF2	ENSCAFP00000058639	ENSCAFP00000063478	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor 2.	0.955
IGF1	IGFBP2	ENSCAFP00000058639	ENSCAFP00000021381	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 2.	0.984
IGF1	IGFBP4	ENSCAFP00000058639	ENSCAFP00000023677	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 4.	0.989
IGF1	IGFBP5	ENSCAFP00000058639	ENSCAFP00000021360	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Insulin like growth factor binding protein 5.	0.994
IGF1	PAPPA	ENSCAFP00000058639	ENSCAFP00000005199	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Pappalysin 1.	0.665
IGF2	IGF1	ENSCAFP00000063478	ENSCAFP00000058639	Insulin like growth factor 2.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.955
IGF2	IGFBP2	ENSCAFP00000063478	ENSCAFP00000021381	Insulin like growth factor 2.	Insulin like growth factor binding protein 2.	0.936
IGF2	IGFBP4	ENSCAFP00000063478	ENSCAFP00000023677	Insulin like growth factor 2.	Insulin like growth factor binding protein 4.	0.887
IGF2	IGFBP5	ENSCAFP00000063478	ENSCAFP00000021360	Insulin like growth factor 2.	Insulin like growth factor binding protein 5.	0.849
IGF2	PAPPA	ENSCAFP00000063478	ENSCAFP00000005199	Insulin like growth factor 2.	Pappalysin 1.	0.668
IGFBP2	IGF1	ENSCAFP00000021381	ENSCAFP00000058639	Insulin like growth factor binding protein 2.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.984
IGFBP2	IGF2	ENSCAFP00000021381	ENSCAFP00000063478	Insulin like growth factor binding protein 2.	Insulin like growth factor 2.	0.936
IGFBP2	IGFBP4	ENSCAFP00000021381	ENSCAFP00000023677	Insulin like growth factor binding protein 2.	Insulin like growth factor binding protein 4.	0.551
IGFBP2	PAPPA	ENSCAFP00000021381	ENSCAFP00000005199	Insulin like growth factor binding protein 2.	Pappalysin 1.	0.537
IGFBP4	IGF1	ENSCAFP00000023677	ENSCAFP00000058639	Insulin like growth factor binding protein 4.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.989
IGFBP4	IGF2	ENSCAFP00000023677	ENSCAFP00000063478	Insulin like growth factor binding protein 4.	Insulin like growth factor 2.	0.887
IGFBP4	IGFBP2	ENSCAFP00000023677	ENSCAFP00000021381	Insulin like growth factor binding protein 4.	Insulin like growth factor binding protein 2.	0.551
IGFBP4	IGFBP5	ENSCAFP00000023677	ENSCAFP00000021360	Insulin like growth factor binding protein 4.	Insulin like growth factor binding protein 5.	0.482
IGFBP4	PAPPA	ENSCAFP00000023677	ENSCAFP00000005199	Insulin like growth factor binding protein 4.	Pappalysin 1.	0.672