STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTOV1PTOV1 extended AT-hook containing adaptor protein. (415 aa)    
Predicted Functional Partners:
KLHDC2
Kelch domain containing 2.
    
 
 0.862
FLOT1
Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.
    
 
 0.632
KLHDC1
Kelch domain containing 1.
    
 
 0.628
FANCM
FA complementation group M.
    
 0.609
CREBBP
CREB binding protein.
   
   0.575
AHSA1
Activator of HSP90 ATPase activity 1.
      
 0.538
ZUP1
Zinc finger containing ubiquitin peptidase 1.
      
 0.518
AFAP1L1
Actin filament associated protein 1 like 1.
    
   0.510
FLOT2
Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.
    
 
 0.505
MED6
Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 
 0.485
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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