STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HECW1HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1. (1619 aa)    
Predicted Functional Partners:
DVL1
Dishevelled segment polarity protein 1.
   
 0.939
GRTP1
Growth hormone regulated TBC protein 1.
   
 
 0.819
RPS27A
Ubiquitin-like domain-containing protein.
    
  0.729
SMURF1
SMAD specific E3 ubiquitin protein ligase 1.
    
 0.699
GABBR2
Gamma-aminobutyric acid type B receptor subunit 2.
   
  
 0.698
UBA52
Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]
    
 0.697
ARRDC1
Arrestin domain containing 1.
    
 
 0.661
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.655
SGK1
Non-specific serine/threonine protein kinase.
   
 0.617
AIF1L
Allograft inflammatory factor 1 like.
   
 
 0.617
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.