C5 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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textmining

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co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

C5

Complement C5. (1611 aa)

Predicted Functional Partners:

C6

0.999

C7

0.998

C9

0.998

C8B

0.998

C5AR2

0.991

C5AR1

0.989

C8A

0.971

C3AR1

0.954

C8G

0.936

C3

0.913

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3	C3AR1	ENSCAFP00000027484	ENSCAFP00000035391	Complement C3.	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.929
C3	C5	ENSCAFP00000027484	ENSCAFP00000005350	Complement C3.	Complement C5.	0.913
C3	C5AR1	ENSCAFP00000027484	ENSCAFP00000006201	Complement C3.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.802
C3	C5AR2	ENSCAFP00000027484	ENSCAFP00000006200	Complement C3.	Complement component 5a receptor 2.	0.729
C3	C6	ENSCAFP00000027484	ENSCAFP00000027446	Complement C3.	Complement C6.	0.684
C3	C7	ENSCAFP00000027484	ENSCAFP00000027458	Complement C3.	Complement C7.	0.622
C3	C8A	ENSCAFP00000027484	ENSCAFP00000049192	Complement C3.	Complement C8 alpha chain.	0.536
C3	C8B	ENSCAFP00000027484	ENSCAFP00000027955	Complement C3.	Complement C8 beta chain.	0.594
C3	C8G	ENSCAFP00000027484	ENSCAFP00000055609	Complement C3.	Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family.	0.488
C3	C9	ENSCAFP00000027484	ENSCAFP00000027486	Complement C3.	Complement C9.	0.725
C3AR1	C3	ENSCAFP00000035391	ENSCAFP00000027484	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement C3.	0.929
C3AR1	C5	ENSCAFP00000035391	ENSCAFP00000005350	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	Complement C5.	0.954
C3AR1	C5AR1	ENSCAFP00000035391	ENSCAFP00000006201	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.452
C5	C3	ENSCAFP00000005350	ENSCAFP00000027484	Complement C5.	Complement C3.	0.913
C5	C3AR1	ENSCAFP00000005350	ENSCAFP00000035391	Complement C5.	Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.954
C5	C5AR1	ENSCAFP00000005350	ENSCAFP00000006201	Complement C5.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.989
C5	C5AR2	ENSCAFP00000005350	ENSCAFP00000006200	Complement C5.	Complement component 5a receptor 2.	0.991
C5	C6	ENSCAFP00000005350	ENSCAFP00000027446	Complement C5.	Complement C6.	0.999
C5	C7	ENSCAFP00000005350	ENSCAFP00000027458	Complement C5.	Complement C7.	0.998
C5	C8A	ENSCAFP00000005350	ENSCAFP00000049192	Complement C5.	Complement C8 alpha chain.	0.971