STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
IRF3Interferon regulatory factor 3. (281 aa)    
Predicted Functional Partners:
TBK1
TANK binding kinase 1.
    
 0.999
CREBBP
CREB binding protein.
    
 0.998
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
    
 0.998
EP300
E1A binding protein p300.
    
 0.993
PIN1
Peptidyl-prolyl cis-trans isomerase.
   
 0.986
IFNB1
Interferon-beta.
    
 0.985
ISG15
ISG15 ubiquitin like modifier.
   
 0.978
TICAM1
TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
    
 0.976
F6Y518_CANLF
IRF-3 domain-containing protein.
   
 0.966
STING1
Transmembrane protein 173.
    
 
 0.964
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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