STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (957 aa)    
Predicted Functional Partners:
UBE2L3
Ubiquitin conjugating enzyme E2 L3; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.655
UBB
Ubiquitin B.
   
 
 0.603
LOC100685053
Ubiquitin-like domain-containing protein.
   
 
 0.603
RPS27A
Ubiquitin-like domain-containing protein.
   
 
 0.589
TRRAP
Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.
   
 
 0.587
ENSCAFP00000050780
Ubiquitin-like domain-containing protein.
   
 
 0.585
PRNP
Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...]
   
 
 0.584
MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family.
   
 
 0.580
DDIT4
DNA damage inducible transcript 4.
   
   0.566
GNG8
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
      
 0.561
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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