STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTH2Parathyroid hormone 2. (99 aa)    
Predicted Functional Partners:
PTH2R
Parathyroid hormone 2 receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.990
PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
    
 0.990
PTH
Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).
     
 0.951
TCAIM
T cell activation inhibitor, mitochondrial.
      
 0.710
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
      
 0.689
LOC610380
Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.
   
 0.500
ITGA2B
Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.
      
 0.465
SCTR
Secretin receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.441
PTGDR2
Prostaglandin D2 receptor 2; Belongs to the G-protein coupled receptor 1 family.
  
   
 0.430
TOR2A
Torsin.
      
 0.406
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.