STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
C15H16orf87Chromosome 15 C16orf87 homolog. (154 aa)    
Predicted Functional Partners:
ARID5B
AT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride m [...]
    
 
 0.816
MIER3
MIER family member 3.
    
   0.786
MIER1
MIER1 transcriptional regulator.
    
   0.786
ANAPC7
Anaphase promoting complex subunit 7.
    
   0.785
ANAPC5
Anaphase promoting complex subunit 5.
    
   0.784
FZR1
Fizzy and cell division cycle 20 related 1.
    
 
 0.782
CDC26
Cell division cycle 26.
    
   0.781
ANAPC1
Anaphase promoting complex subunit 1.
    
   0.781
CDC27
Cell division cycle 27.
    
   0.780
ANAPC2
Anaphase promoting complex subunit 2; Belongs to the cullin family.
    
   0.779
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.