node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CIDEA | COX7A1 | ENSCAFP00000031933 | ENSCAFP00000009836 | Cell death inducing DFFA like effector a. | Cytochrome c oxidase subunit 7A1, mitochondrial. | 0.695 |
CIDEA | LEP | ENSCAFP00000031933 | ENSCAFP00000002433 | Cell death inducing DFFA like effector a. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | 0.633 |
CIDEA | LIPE | ENSCAFP00000031933 | ENSCAFP00000007187 | Cell death inducing DFFA like effector a. | Lipase E, hormone sensitive type. | 0.674 |
CIDEA | PLIN1 | ENSCAFP00000031933 | ENSCAFP00000017642 | Cell death inducing DFFA like effector a. | Perilipin; Belongs to the perilipin family. | 0.677 |
CIDEA | PPARG | ENSCAFP00000031933 | ENSCAFP00000007423 | Cell death inducing DFFA like effector a. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.665 |
CIDEA | PRDM16 | ENSCAFP00000031933 | ENSCAFP00000039059 | Cell death inducing DFFA like effector a. | PR/SET domain 16. | 0.851 |
CIDEA | UCP1 | ENSCAFP00000031933 | ENSCAFP00000005489 | Cell death inducing DFFA like effector a. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.705 |
COX7A1 | CIDEA | ENSCAFP00000009836 | ENSCAFP00000031933 | Cytochrome c oxidase subunit 7A1, mitochondrial. | Cell death inducing DFFA like effector a. | 0.695 |
COX7A1 | PRDM16 | ENSCAFP00000009836 | ENSCAFP00000039059 | Cytochrome c oxidase subunit 7A1, mitochondrial. | PR/SET domain 16. | 0.620 |
COX7A1 | UCP1 | ENSCAFP00000009836 | ENSCAFP00000005489 | Cytochrome c oxidase subunit 7A1, mitochondrial. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.541 |
LEP | CIDEA | ENSCAFP00000002433 | ENSCAFP00000031933 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Cell death inducing DFFA like effector a. | 0.633 |
LEP | LIPE | ENSCAFP00000002433 | ENSCAFP00000007187 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Lipase E, hormone sensitive type. | 0.712 |
LEP | MC4R | ENSCAFP00000002433 | ENSCAFP00000000126 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Melanocortin-4 receptor. | 0.859 |
LEP | PCK1 | ENSCAFP00000002433 | ENSCAFP00000046431 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Phosphoenolpyruvate carboxykinase 1. | 0.445 |
LEP | PLIN1 | ENSCAFP00000002433 | ENSCAFP00000017642 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Perilipin; Belongs to the perilipin family. | 0.723 |
LEP | POMC | ENSCAFP00000002433 | ENSCAFP00000006163 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Proopiomelanocortin. | 0.996 |
LEP | PPARG | ENSCAFP00000002433 | ENSCAFP00000007423 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.844 |
LEP | PRDM16 | ENSCAFP00000002433 | ENSCAFP00000039059 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | PR/SET domain 16. | 0.580 |
LEP | UCP1 | ENSCAFP00000002433 | ENSCAFP00000005489 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.768 |
LIPE | CIDEA | ENSCAFP00000007187 | ENSCAFP00000031933 | Lipase E, hormone sensitive type. | Cell death inducing DFFA like effector a. | 0.674 |