STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)    
Predicted Functional Partners:
VPS26B
VPS26, retromer complex component B.
   
 0.999
VPS26A
VPS26, retromer complex component A.
   
 0.997
TBC1D5
TBC1 domain family member 5.
   
 0.997
SNX2
Sorting nexin 2.
   
 0.992
ENSCAFP00000047301
Uncharacterized protein.
   
 0.990
VPS29
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
   
 0.989
ENSCAFP00000052292
PX domain-containing protein.
   
 0.983
ENSCAFP00000055724
PX domain-containing protein.
   
 0.983
SNX1
Sorting nexin 1.
   
 0.980
SNX27
Sorting nexin 27.
   
 0.952
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.