STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FOXO3Forkhead box O3. (671 aa)    
Predicted Functional Partners:
SIRT1
Sirtuin 1.
    
 0.987
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
    
 
 0.970
AKT2
AKT serine/threonine kinase 2.
    
 0.969
AKT1
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.968
AKT3
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.958
STAT3
Signal transducer and activator of transcription.
   
 0.957
SMAD2
Mothers against decapentaplegic homolog.
    
 0.955
SGK1
Non-specific serine/threonine protein kinase.
    
 0.938
SMAD3
Mothers against decapentaplegic homolog.
    
 0.933
MAPK1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
    
 0.933
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.