E2QRQ7_CANLF protein (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

E2QRQ7_CANLF

Ig-like domain-containing protein. (186 aa)

Predicted Functional Partners:

CD3G

0.785

ZAP70

0.781

CD3E

0.780

LAT

0.779

CD247

0.778

DLA-DRA

0.772

CD3D

0.756

PLCG1

0.729

E2R5X5_CANLF

0.680

E2RKE1_CANLF

0.680

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD3D	ENSCAFP00000041707	ENSCAFP00000038117	Uncharacterized protein.	CD3d molecule.	0.999
CD247	CD3E	ENSCAFP00000041707	ENSCAFP00000052947	Uncharacterized protein.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.999
CD247	CD3G	ENSCAFP00000041707	ENSCAFP00000018809	Uncharacterized protein.	CD3g molecule.	0.999
CD247	DLA-DRA	ENSCAFP00000041707	ENSCAFP00000045482	Uncharacterized protein.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.940
CD247	E2QRQ7_CANLF	ENSCAFP00000041707	ENSCAFP00000005672	Uncharacterized protein.	Ig-like domain-containing protein.	0.778
CD247	E2R5X5_CANLF	ENSCAFP00000041707	ENSCAFP00000016337	Uncharacterized protein.	IGv domain-containing protein.	0.594
CD247	E2RKE1_CANLF	ENSCAFP00000041707	ENSCAFP00000033289	Uncharacterized protein.	Ig-like domain-containing protein.	0.491
CD247	LAT	ENSCAFP00000041707	ENSCAFP00000025545	Uncharacterized protein.	Linker for activation of T cells.	0.775
CD247	PLCG1	ENSCAFP00000041707	ENSCAFP00000046841	Uncharacterized protein.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.681
CD247	ZAP70	ENSCAFP00000041707	ENSCAFP00000047083	Uncharacterized protein.	Tyrosine-protein kinase.	0.999
CD3D	CD247	ENSCAFP00000038117	ENSCAFP00000041707	CD3d molecule.	Uncharacterized protein.	0.999
CD3D	CD3E	ENSCAFP00000038117	ENSCAFP00000052947	CD3d molecule.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.999
CD3D	CD3G	ENSCAFP00000038117	ENSCAFP00000018809	CD3d molecule.	CD3g molecule.	0.999
CD3D	DLA-DRA	ENSCAFP00000038117	ENSCAFP00000045482	CD3d molecule.	Ig-like domain-containing protein; Belongs to the MHC class II family.	0.712
CD3D	E2QRQ7_CANLF	ENSCAFP00000038117	ENSCAFP00000005672	CD3d molecule.	Ig-like domain-containing protein.	0.756
CD3D	E2R5X5_CANLF	ENSCAFP00000038117	ENSCAFP00000016337	CD3d molecule.	IGv domain-containing protein.	0.582
CD3D	E2RKE1_CANLF	ENSCAFP00000038117	ENSCAFP00000033289	CD3d molecule.	Ig-like domain-containing protein.	0.472
CD3D	LAT	ENSCAFP00000038117	ENSCAFP00000025545	CD3d molecule.	Linker for activation of T cells.	0.846
CD3D	PLCG1	ENSCAFP00000038117	ENSCAFP00000046841	CD3d molecule.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.428
CD3D	ZAP70	ENSCAFP00000038117	ENSCAFP00000047083	CD3d molecule.	Tyrosine-protein kinase.	0.997