STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC475521Cationic trypsin. (246 aa)    
Predicted Functional Partners:
ENSCAFP00000050972
Uncharacterized protein.
 
  
   0.897
F2RL1
Protease-activated receptor 2.
    
 0.876
F2RL3
F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.
    
 0.839
F2R
Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.
    
 0.825
CTSG
Granzyme B; Belongs to the peptidase S1 family.
  
  
0.820
LOC479649
Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.
  
 
0.813
F2RL2
Coagulation factor II thrombin receptor like 2.
    
  0.805
SPINT2
Uncharacterized protein.
    
 
 0.784
AMBP
Alpha-1-microglobulin/bikunin precursor.
   
 
 0.756
APP
Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]
    
 
 0.728
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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