NTF4 protein (Canis lupus familiaris) - STRING interaction network

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NTF4

Neurotrophin 4; Belongs to the NGF-beta family. (216 aa)

Predicted Functional Partners:

NTRK2

0.998

NTRK3

0.973

NGFR

0.952

NTRK1

0.932

EGFR

0.885

ERBB4

0.881

RET

0.845

BDNF

0.831

PDGFRB

0.822

IGF1R

0.819

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	EGFR	ENSCAFP00000014984	ENSCAFP00000005164	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Receptor protein-tyrosine kinase.	0.916
BDNF	ERBB4	ENSCAFP00000014984	ENSCAFP00000048210	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Receptor protein-tyrosine kinase.	0.924
BDNF	IGF1R	ENSCAFP00000014984	ENSCAFP00000043796	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.853
BDNF	NGFR	ENSCAFP00000014984	ENSCAFP00000042847	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Nerve growth factor receptor.	0.962
BDNF	NTF4	ENSCAFP00000014984	ENSCAFP00000005718	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Neurotrophin 4; Belongs to the NGF-beta family.	0.831
BDNF	NTRK1	ENSCAFP00000014984	ENSCAFP00000052728	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.971
BDNF	NTRK2	ENSCAFP00000014984	ENSCAFP00000063233	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.997
BDNF	NTRK3	ENSCAFP00000014984	ENSCAFP00000043465	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Tyrosine-protein kinase receptor.	0.964
BDNF	PDGFRB	ENSCAFP00000014984	ENSCAFP00000000714	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...]	0.852
BDNF	RET	ENSCAFP00000014984	ENSCAFP00000046537	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.858
EGFR	BDNF	ENSCAFP00000005164	ENSCAFP00000014984	Receptor protein-tyrosine kinase.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.916
EGFR	ERBB4	ENSCAFP00000005164	ENSCAFP00000048210	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.966
EGFR	IGF1R	ENSCAFP00000005164	ENSCAFP00000043796	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.946
EGFR	NTF4	ENSCAFP00000005164	ENSCAFP00000005718	Receptor protein-tyrosine kinase.	Neurotrophin 4; Belongs to the NGF-beta family.	0.885
EGFR	NTRK1	ENSCAFP00000005164	ENSCAFP00000052728	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.759
EGFR	NTRK2	ENSCAFP00000005164	ENSCAFP00000063233	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.877
EGFR	NTRK3	ENSCAFP00000005164	ENSCAFP00000043465	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.779
EGFR	PDGFRB	ENSCAFP00000005164	ENSCAFP00000000714	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...]	0.974
EGFR	RET	ENSCAFP00000005164	ENSCAFP00000046537	Receptor protein-tyrosine kinase.	Ret proto-oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.949
ERBB4	BDNF	ENSCAFP00000048210	ENSCAFP00000014984	Receptor protein-tyrosine kinase.	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...]	0.924