ITGB1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ITGB1

Integrin beta; Belongs to the integrin beta chain family. (820 aa)

Predicted Functional Partners:

ITGA5

0.999

ITGA6

0.999

ITGA4

0.998

ILK

0.997

ITGAV

0.997

ITGA2

0.995

FN1

0.995

ITGA3

0.988

ITGA7

0.987

PELO

0.984

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FN1	ITGA2	ENSCAFP00000066679	ENSCAFP00000027208	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	0.810
FN1	ITGA3	ENSCAFP00000066679	ENSCAFP00000025006	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.958
FN1	ITGA4	ENSCAFP00000066679	ENSCAFP00000020903	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.601
FN1	ITGA5	ENSCAFP00000066679	ENSCAFP00000009742	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.997
FN1	ITGA6	ENSCAFP00000066679	ENSCAFP00000054417	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.813
FN1	ITGA7	ENSCAFP00000066679	ENSCAFP00000064043	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.799
FN1	ITGAV	ENSCAFP00000066679	ENSCAFP00000050990	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.991
FN1	ITGB1	ENSCAFP00000066679	ENSCAFP00000005722	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.995
FN1	PELO	ENSCAFP00000066679	ENSCAFP00000055731	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 1; Belongs to the integrin alpha chain family.	0.785
ILK	ITGA4	ENSCAFP00000033861	ENSCAFP00000020903	Integrin linked kinase.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.421
ILK	ITGA5	ENSCAFP00000033861	ENSCAFP00000009742	Integrin linked kinase.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.947
ILK	ITGA7	ENSCAFP00000033861	ENSCAFP00000064043	Integrin linked kinase.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.584
ILK	ITGB1	ENSCAFP00000033861	ENSCAFP00000005722	Integrin linked kinase.	Integrin beta; Belongs to the integrin beta chain family.	0.997
ITGA2	FN1	ENSCAFP00000027208	ENSCAFP00000066679	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	0.810
ITGA2	ITGA3	ENSCAFP00000027208	ENSCAFP00000025006	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 3; Belongs to the integrin alpha chain family.	0.750
ITGA2	ITGA4	ENSCAFP00000027208	ENSCAFP00000020903	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 4; Belongs to the integrin alpha chain family.	0.410
ITGA2	ITGA5	ENSCAFP00000027208	ENSCAFP00000009742	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 5; Belongs to the integrin alpha chain family.	0.516
ITGA2	ITGA6	ENSCAFP00000027208	ENSCAFP00000054417	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.821
ITGA2	ITGA7	ENSCAFP00000027208	ENSCAFP00000064043	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha 7; Belongs to the integrin alpha chain family.	0.711
ITGA2	ITGAV	ENSCAFP00000027208	ENSCAFP00000050990	Integrin subunit alpha 2; Belongs to the integrin alpha chain family.	Integrin subunit alpha V; Belongs to the integrin alpha chain family.	0.697