STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LDAHLipid droplet associated hydrolase. (325 aa)    
Predicted Functional Partners:
SQOR
Pyr_redox_2 domain-containing protein.
      
 0.811
MAGI2
Membrane associated guanylate kinase, WW and PDZ domain containing 2.
      
 0.674
GMDS
GDP-mannose 4,6-dehydratase.
      
 0.643
CD226
CD226 molecule.
   
  
 0.576
GPC2
Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
      
 0.560
ADGRG6
Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family.
      
 0.485
SLC31A2
Solute carrier family 31 member 2.
   
  
 0.431
DLC1
Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity).
   
  
 0.430
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.