PPP1R15A protein (Canis lupus familiaris) - STRING interaction network

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Score

PPP1R15A

Protein phosphatase 1 regulatory subunit 15A. (771 aa)

Predicted Functional Partners:

EIF2S1

0.950

ATF4

0.935

DDIT3

0.537

HSPA5

0.450

EIF2AK1

0.446

PRAME

0.436

BDP1

0.408

XBP1

0.408

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	DDIT3	ENSCAFP00000001900	ENSCAFP00000039330	Activating transcription factor 4.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.991
ATF4	EIF2S1	ENSCAFP00000001900	ENSCAFP00000034264	Activating transcription factor 4.	Eukaryotic translation initiation factor 2 subunit alpha.	0.958
ATF4	HSPA5	ENSCAFP00000001900	ENSCAFP00000029957	Activating transcription factor 4.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.796
ATF4	PPP1R15A	ENSCAFP00000001900	ENSCAFP00000005780	Activating transcription factor 4.	Protein phosphatase 1 regulatory subunit 15A.	0.935
ATF4	XBP1	ENSCAFP00000001900	ENSCAFP00000017593	Activating transcription factor 4.	BZIP domain-containing protein.	0.872
BDP1	PPP1R15A	ENSCAFP00000011585	ENSCAFP00000005780	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB.	Protein phosphatase 1 regulatory subunit 15A.	0.408
DDIT3	ATF4	ENSCAFP00000039330	ENSCAFP00000001900	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Activating transcription factor 4.	0.991
DDIT3	EIF2S1	ENSCAFP00000039330	ENSCAFP00000034264	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Eukaryotic translation initiation factor 2 subunit alpha.	0.659
DDIT3	HSPA5	ENSCAFP00000039330	ENSCAFP00000029957	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.791
DDIT3	PPP1R15A	ENSCAFP00000039330	ENSCAFP00000005780	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Protein phosphatase 1 regulatory subunit 15A.	0.537
DDIT3	XBP1	ENSCAFP00000039330	ENSCAFP00000017593	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	BZIP domain-containing protein.	0.983
EIF2AK1	EIF2S1	ENSCAFP00000023026	ENSCAFP00000034264	Eukaryotic translation initiation factor 2 alpha kinase 1.	Eukaryotic translation initiation factor 2 subunit alpha.	0.981
EIF2AK1	PPP1R15A	ENSCAFP00000023026	ENSCAFP00000005780	Eukaryotic translation initiation factor 2 alpha kinase 1.	Protein phosphatase 1 regulatory subunit 15A.	0.446
EIF2S1	ATF4	ENSCAFP00000034264	ENSCAFP00000001900	Eukaryotic translation initiation factor 2 subunit alpha.	Activating transcription factor 4.	0.958
EIF2S1	DDIT3	ENSCAFP00000034264	ENSCAFP00000039330	Eukaryotic translation initiation factor 2 subunit alpha.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.659
EIF2S1	EIF2AK1	ENSCAFP00000034264	ENSCAFP00000023026	Eukaryotic translation initiation factor 2 subunit alpha.	Eukaryotic translation initiation factor 2 alpha kinase 1.	0.981
EIF2S1	HSPA5	ENSCAFP00000034264	ENSCAFP00000029957	Eukaryotic translation initiation factor 2 subunit alpha.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.698
EIF2S1	PPP1R15A	ENSCAFP00000034264	ENSCAFP00000005780	Eukaryotic translation initiation factor 2 subunit alpha.	Protein phosphatase 1 regulatory subunit 15A.	0.950
EIF2S1	XBP1	ENSCAFP00000034264	ENSCAFP00000017593	Eukaryotic translation initiation factor 2 subunit alpha.	BZIP domain-containing protein.	0.598
HSPA5	ATF4	ENSCAFP00000029957	ENSCAFP00000001900	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	Activating transcription factor 4.	0.796