TXNRD3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TXNRD3

Thioredoxin reductase 3. (464 aa)

Predicted Functional Partners:

BCKDHA

0.888

PDHX

0.812

DLAT

0.812

DBT

0.812

DLST

0.812

GPX2

0.808

SELENOT

0.794

UROC1

0.780

SELENOO

0.777

BCKDHB

0.764

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCKDHA	BCKDHB	ENSCAFP00000007450	ENSCAFP00000004212	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Branched chain keto acid dehydrogenase E1 subunit beta.	0.999
BCKDHA	DBT	ENSCAFP00000007450	ENSCAFP00000029657	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.996
BCKDHA	DLAT	ENSCAFP00000007450	ENSCAFP00000020671	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.978
BCKDHA	DLST	ENSCAFP00000007450	ENSCAFP00000061524	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Dihydrolipoamide S-succinyltransferase.	0.969
BCKDHA	PDHX	ENSCAFP00000007450	ENSCAFP00000010269	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.975
BCKDHA	TXNRD3	ENSCAFP00000007450	ENSCAFP00000005807	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	Thioredoxin reductase 3.	0.888
BCKDHB	BCKDHA	ENSCAFP00000004212	ENSCAFP00000007450	Branched chain keto acid dehydrogenase E1 subunit beta.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
BCKDHB	DBT	ENSCAFP00000004212	ENSCAFP00000029657	Branched chain keto acid dehydrogenase E1 subunit beta.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.999
BCKDHB	DLAT	ENSCAFP00000004212	ENSCAFP00000020671	Branched chain keto acid dehydrogenase E1 subunit beta.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.938
BCKDHB	DLST	ENSCAFP00000004212	ENSCAFP00000061524	Branched chain keto acid dehydrogenase E1 subunit beta.	Dihydrolipoamide S-succinyltransferase.	0.904
BCKDHB	PDHX	ENSCAFP00000004212	ENSCAFP00000010269	Branched chain keto acid dehydrogenase E1 subunit beta.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.969
BCKDHB	TXNRD3	ENSCAFP00000004212	ENSCAFP00000005807	Branched chain keto acid dehydrogenase E1 subunit beta.	Thioredoxin reductase 3.	0.764
DBT	BCKDHA	ENSCAFP00000029657	ENSCAFP00000007450	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.996
DBT	BCKDHB	ENSCAFP00000029657	ENSCAFP00000004212	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.999
DBT	DLAT	ENSCAFP00000029657	ENSCAFP00000020671	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.631
DBT	DLST	ENSCAFP00000029657	ENSCAFP00000061524	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide S-succinyltransferase.	0.560
DBT	PDHX	ENSCAFP00000029657	ENSCAFP00000010269	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.582
DBT	TXNRD3	ENSCAFP00000029657	ENSCAFP00000005807	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	Thioredoxin reductase 3.	0.812
DLAT	BCKDHA	ENSCAFP00000020671	ENSCAFP00000007450	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.978
DLAT	BCKDHB	ENSCAFP00000020671	ENSCAFP00000004212	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Branched chain keto acid dehydrogenase E1 subunit beta.	0.938