Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
BRAFB-Raf proto-oncogene, serine/threonine kinase. (772 aa)    
Predicted Functional Partners:
KRAS
KRAS proto-oncogene, GTPase.
   
 0.996
NRAS
Uncharacterized protein.
   
 0.995
YWHAB
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family.
    
 0.991
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
  
0.990
ARAF
A-Raf proto-oncogene, serine/threonine kinase.
  
0.990
HRAS
Uncharacterized protein.
   
 0.990
RAP1B
RAP1B, member of RAS oncogene family.
    
 0.977
RAP1A
RAP1A, member of RAS oncogene family.
   
 0.977
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity).
   
0.975
YWHAE
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family.
    
 0.974
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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