FAT4 protein (Canis lupus familiaris) - STRING interaction network

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FAT4

FAT atypical cadherin 4. (4982 aa)

Predicted Functional Partners:

CTNNB1

0.748

GDNF

0.741

DCHS1

0.704

DCHS2

0.663

EPO

0.660

TBC1D32

0.635

APOB

0.614

IRX3

0.610

CCDC137

0.591

RHOV

0.582

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	FAT4	ENSCAFP00000005806	ENSCAFP00000005893	Apolipoprotein B.	FAT atypical cadherin 4.	0.614
APOB	RHOV	ENSCAFP00000005806	ENSCAFP00000040118	Apolipoprotein B.	Ras homolog family member V.	0.575
CCDC137	FAT4	ENSCAFP00000033939	ENSCAFP00000005893	Coiled-coil domain containing 137.	FAT atypical cadherin 4.	0.591
CTNNB1	DCHS1	ENSCAFP00000007783	ENSCAFP00000009817	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Dachsous cadherin-related 1.	0.540
CTNNB1	DCHS2	ENSCAFP00000007783	ENSCAFP00000012289	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Dachsous cadherin-related 2.	0.951
CTNNB1	EPO	ENSCAFP00000007783	ENSCAFP00000020937	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	0.523
CTNNB1	FAT4	ENSCAFP00000007783	ENSCAFP00000005893	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	FAT atypical cadherin 4.	0.748
CTNNB1	GDNF	ENSCAFP00000007783	ENSCAFP00000042228	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Glial cell derived neurotrophic factor.	0.825
CTNNB1	TBC1D32	ENSCAFP00000007783	ENSCAFP00000057847	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	TBC1 domain family member 32.	0.462
DCHS1	CTNNB1	ENSCAFP00000009817	ENSCAFP00000007783	Dachsous cadherin-related 1.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.540
DCHS1	DCHS2	ENSCAFP00000009817	ENSCAFP00000012289	Dachsous cadherin-related 1.	Dachsous cadherin-related 2.	0.751
DCHS1	FAT4	ENSCAFP00000009817	ENSCAFP00000005893	Dachsous cadherin-related 1.	FAT atypical cadherin 4.	0.704
DCHS1	GDNF	ENSCAFP00000009817	ENSCAFP00000042228	Dachsous cadherin-related 1.	Glial cell derived neurotrophic factor.	0.443
DCHS2	CTNNB1	ENSCAFP00000012289	ENSCAFP00000007783	Dachsous cadherin-related 2.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.951
DCHS2	DCHS1	ENSCAFP00000012289	ENSCAFP00000009817	Dachsous cadherin-related 2.	Dachsous cadherin-related 1.	0.751
DCHS2	FAT4	ENSCAFP00000012289	ENSCAFP00000005893	Dachsous cadherin-related 2.	FAT atypical cadherin 4.	0.663
DCHS2	GDNF	ENSCAFP00000012289	ENSCAFP00000042228	Dachsous cadherin-related 2.	Glial cell derived neurotrophic factor.	0.443
EPO	CTNNB1	ENSCAFP00000020937	ENSCAFP00000007783	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.523
EPO	FAT4	ENSCAFP00000020937	ENSCAFP00000005893	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	FAT atypical cadherin 4.	0.660
EPO	GDNF	ENSCAFP00000020937	ENSCAFP00000042228	Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.	Glial cell derived neurotrophic factor.	0.704