STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPHK2Sphingosine kinase 2. (733 aa)    
Predicted Functional Partners:
ASAH2
Neutral ceramidase.
    
 0.973
SGPL1
Sphingosine-1-phosphate lyase 1.
   
 0.965
ASAH1
N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family.
     
 0.943
ACER3
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
    
 0.940
SGPP1
Sphingosine-1-phosphate phosphatase 1.
   
 0.937
ACER2
Alkaline ceramidase 2.
    
 0.934
ACER1
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
    
 0.932
CERS2
Ceramide synthase 2.
     
 0.925
DEGS1
Delta 4-desaturase, sphingolipid 1.
    
 0.925
CERS4
Ceramide synthase 4.
     
 0.923
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.