STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.935
SPRY2
Sprouty RTK signaling antagonist 2.
  
0.776
MDFI
MyoD family inhibitor.
    
 
 0.704
GRB2
Growth factor receptor bound protein 2.
    
 
 0.697
HOXA1
Homeobox A1.
    
 
 0.683
PDGFC
Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.
      
 0.667
ZNF23
Zinc finger protein 23.
    
   0.623
NFIC
Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
      
 0.606
SLC6A1
Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
      
 0.601
CBLB
Cbl proto-oncogene B.
    
 
 0.599
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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