node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESR1 | NCOA1 | ENSCAFP00000000624 | ENSCAFP00000006049 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor coactivator. | 0.994 |
ESR1 | NCOR1 | ENSCAFP00000000624 | ENSCAFP00000053648 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor corepressor 1. | 0.977 |
ESR1 | NCOR2 | ENSCAFP00000000624 | ENSCAFP00000010374 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Nuclear receptor corepressor 2. | 0.839 |
ESR1 | PGR | ENSCAFP00000000624 | ENSCAFP00000005906 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.944 |
ESR1 | PIK3CA | ENSCAFP00000000624 | ENSCAFP00000048355 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.814 |
ESR1 | PIK3R1 | ENSCAFP00000000624 | ENSCAFP00000011322 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.808 |
ESR1 | PIK3R2 | ENSCAFP00000000624 | ENSCAFP00000022072 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Uncharacterized protein. | 0.660 |
ESR1 | PIK3R3 | ENSCAFP00000000624 | ENSCAFP00000006438 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Uncharacterized protein. | 0.661 |
ESR1 | PRKACA | ENSCAFP00000000624 | ENSCAFP00000053880 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] | 0.950 |
ESR1 | PRKACB | ENSCAFP00000000624 | ENSCAFP00000030135 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.949 |
NCOA1 | ESR1 | ENSCAFP00000006049 | ENSCAFP00000000624 | Nuclear receptor coactivator. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.994 |
NCOA1 | NCOR1 | ENSCAFP00000006049 | ENSCAFP00000053648 | Nuclear receptor coactivator. | Nuclear receptor corepressor 1. | 0.746 |
NCOA1 | NCOR2 | ENSCAFP00000006049 | ENSCAFP00000010374 | Nuclear receptor coactivator. | Nuclear receptor corepressor 2. | 0.740 |
NCOA1 | PGR | ENSCAFP00000006049 | ENSCAFP00000005906 | Nuclear receptor coactivator. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.944 |
NCOR1 | ESR1 | ENSCAFP00000053648 | ENSCAFP00000000624 | Nuclear receptor corepressor 1. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.977 |
NCOR1 | NCOA1 | ENSCAFP00000053648 | ENSCAFP00000006049 | Nuclear receptor corepressor 1. | Nuclear receptor coactivator. | 0.746 |
NCOR1 | NCOR2 | ENSCAFP00000053648 | ENSCAFP00000010374 | Nuclear receptor corepressor 1. | Nuclear receptor corepressor 2. | 0.930 |
NCOR1 | PGR | ENSCAFP00000053648 | ENSCAFP00000005906 | Nuclear receptor corepressor 1. | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor (By similarity). [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily. | 0.934 |
NCOR2 | ESR1 | ENSCAFP00000010374 | ENSCAFP00000000624 | Nuclear receptor corepressor 2. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.839 |
NCOR2 | NCOA1 | ENSCAFP00000010374 | ENSCAFP00000006049 | Nuclear receptor corepressor 2. | Nuclear receptor coactivator. | 0.740 |