STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
JCADJunctional cadherin 5 associated. (1364 aa)    
Predicted Functional Partners:
LAT
Linker for activation of T cells.
      
 0.591
TJP1
Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...]
    
   0.573
TTC7A
Tetratricopeptide repeat domain 7A.
    
   0.565
UGCG
UDP-glucose ceramide glucosyltransferase.
      
 0.473
ARHGEF25
Rho guanine nucleotide exchange factor 25.
      
 0.426
GUCA2B
Guanylate cyclase activator 2B.
      
 0.426
NR4A3
Nuclear receptor subfamily 4 group A member 3.
      
 0.422
EGR3
Early growth response 3.
      
 0.421
MTPAP
Mitochondrial poly(A) polymerase.
      
 0.411
TRIOBP
TRIO and F-actin binding protein.
      
 0.404
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.