TAL1 protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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[Homology]

Score

TAL1

TAL bHLH transcription factor 1, erythroid differentiation factor. (458 aa)

Predicted Functional Partners:

LMO2

0.994

TCF3

0.981

GATA1

0.977

LDB1

0.927

GATA2

0.926

TCF12

0.915

LMO1

0.870

RUNX1

0.869

CBFA2T3

0.852

EP300

0.823

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBFA2T3	LDB1	ENSCAFP00000045885	ENSCAFP00000014734	CBFA2/RUNX1 translocation partner 3.	LIM domain binding 1.	0.709
CBFA2T3	RUNX1	ENSCAFP00000045885	ENSCAFP00000014111	CBFA2/RUNX1 translocation partner 3.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.807
CBFA2T3	TAL1	ENSCAFP00000045885	ENSCAFP00000005977	CBFA2/RUNX1 translocation partner 3.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.852
CBFA2T3	TCF12	ENSCAFP00000045885	ENSCAFP00000023912	CBFA2/RUNX1 translocation partner 3.	Transcription factor 12.	0.620
CBFA2T3	TCF3	ENSCAFP00000045885	ENSCAFP00000028831	CBFA2/RUNX1 translocation partner 3.	Transcription factor 3.	0.656
EP300	GATA1	ENSCAFP00000001585	ENSCAFP00000022898	E1A binding protein p300.	GATA binding protein 1.	0.653
EP300	GATA2	ENSCAFP00000001585	ENSCAFP00000006152	E1A binding protein p300.	GATA binding protein 2.	0.430
EP300	RUNX1	ENSCAFP00000001585	ENSCAFP00000014111	E1A binding protein p300.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.673
EP300	TAL1	ENSCAFP00000001585	ENSCAFP00000005977	E1A binding protein p300.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.823
EP300	TCF12	ENSCAFP00000001585	ENSCAFP00000023912	E1A binding protein p300.	Transcription factor 12.	0.561
EP300	TCF3	ENSCAFP00000001585	ENSCAFP00000028831	E1A binding protein p300.	Transcription factor 3.	0.843
GATA1	EP300	ENSCAFP00000022898	ENSCAFP00000001585	GATA binding protein 1.	E1A binding protein p300.	0.653
GATA1	GATA2	ENSCAFP00000022898	ENSCAFP00000006152	GATA binding protein 1.	GATA binding protein 2.	0.439
GATA1	LDB1	ENSCAFP00000022898	ENSCAFP00000014734	GATA binding protein 1.	LIM domain binding 1.	0.671
GATA1	LMO1	ENSCAFP00000022898	ENSCAFP00000054459	GATA binding protein 1.	LIM domain only 1.	0.672
GATA1	LMO2	ENSCAFP00000022898	ENSCAFP00000010588	GATA binding protein 1.	LIM domain only 2.	0.964
GATA1	RUNX1	ENSCAFP00000022898	ENSCAFP00000014111	GATA binding protein 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.762
GATA1	TAL1	ENSCAFP00000022898	ENSCAFP00000005977	GATA binding protein 1.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.977
GATA1	TCF12	ENSCAFP00000022898	ENSCAFP00000023912	GATA binding protein 1.	Transcription factor 12.	0.573
GATA1	TCF3	ENSCAFP00000022898	ENSCAFP00000028831	GATA binding protein 1.	Transcription factor 3.	0.659