HIPK2 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

HIPK2

Homeodomain interacting protein kinase 2. (1286 aa)

Predicted Functional Partners:

TP53

0.997

HIPK1

0.989

DAXX

0.944

HIPK3

0.921

PIN1

0.915

RASSF5

0.902

HIPK4

0.892

SIAH1

0.892

PML

0.845

AXIN1

0.837

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	HIPK1	ENSCAFP00000054479	ENSCAFP00000013694	Axin 1.	Homeodomain interacting protein kinase 1.	0.418
AXIN1	HIPK2	ENSCAFP00000054479	ENSCAFP00000006003	Axin 1.	Homeodomain interacting protein kinase 2.	0.837
AXIN1	HIPK3	ENSCAFP00000054479	ENSCAFP00000038768	Axin 1.	Homeodomain interacting protein kinase 3.	0.418
AXIN1	HIPK4	ENSCAFP00000054479	ENSCAFP00000007985	Axin 1.	Homeodomain interacting protein kinase 4.	0.418
AXIN1	SIAH1	ENSCAFP00000054479	ENSCAFP00000063213	Axin 1.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.866
AXIN1	TP53	ENSCAFP00000054479	ENSCAFP00000064590	Axin 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.868
DAXX	HIPK1	ENSCAFP00000048726	ENSCAFP00000013694	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	Homeodomain interacting protein kinase 1.	0.833
DAXX	HIPK2	ENSCAFP00000048726	ENSCAFP00000006003	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	Homeodomain interacting protein kinase 2.	0.944
DAXX	HIPK3	ENSCAFP00000048726	ENSCAFP00000038768	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	Homeodomain interacting protein kinase 3.	0.742
DAXX	HIPK4	ENSCAFP00000048726	ENSCAFP00000007985	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	Homeodomain interacting protein kinase 4.	0.765
DAXX	PML	ENSCAFP00000048726	ENSCAFP00000049416	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	Promyelocytic leukemia.	0.962
DAXX	TP53	ENSCAFP00000048726	ENSCAFP00000064590	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.994
HIPK1	AXIN1	ENSCAFP00000013694	ENSCAFP00000054479	Homeodomain interacting protein kinase 1.	Axin 1.	0.418
HIPK1	DAXX	ENSCAFP00000013694	ENSCAFP00000048726	Homeodomain interacting protein kinase 1.	Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]	0.833
HIPK1	HIPK2	ENSCAFP00000013694	ENSCAFP00000006003	Homeodomain interacting protein kinase 1.	Homeodomain interacting protein kinase 2.	0.989
HIPK1	HIPK3	ENSCAFP00000013694	ENSCAFP00000038768	Homeodomain interacting protein kinase 1.	Homeodomain interacting protein kinase 3.	0.958
HIPK1	HIPK4	ENSCAFP00000013694	ENSCAFP00000007985	Homeodomain interacting protein kinase 1.	Homeodomain interacting protein kinase 4.	0.661
HIPK1	PML	ENSCAFP00000013694	ENSCAFP00000049416	Homeodomain interacting protein kinase 1.	Promyelocytic leukemia.	0.654
HIPK1	RASSF5	ENSCAFP00000013694	ENSCAFP00000053216	Homeodomain interacting protein kinase 1.	Ras association domain family member 5.	0.904
HIPK1	TP53	ENSCAFP00000013694	ENSCAFP00000064590	Homeodomain interacting protein kinase 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.982