FRK protein (Canis lupus familiaris) - STRING interaction network

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Score

FRK

Tyrosine-protein kinase. (505 aa)

Predicted Functional Partners:

MIPOL1

0.967

MST1R

0.928

PTEN

0.922

BNIP2

0.840

EGFR

0.818

E2RBZ7_CANLF

0.765

SH2D1A

0.702

KIAA1328

0.679

J9JHI0_CANLF

0.679

MET

0.656

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNIP2	FRK	ENSCAFP00000051399	ENSCAFP00000006021	BCL2 interacting protein 2.	Tyrosine-protein kinase.	0.840
E2RBZ7_CANLF	FRK	ENSCAFP00000017903	ENSCAFP00000006021	Uncharacterized protein.	Tyrosine-protein kinase.	0.765
E2RBZ7_CANLF	MET	ENSCAFP00000017903	ENSCAFP00000041478	Uncharacterized protein.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.630
E2RBZ7_CANLF	MST1R	ENSCAFP00000017903	ENSCAFP00000031338	Uncharacterized protein.	Macrophage stimulating 1 receptor.	0.630
EGFR	FRK	ENSCAFP00000005164	ENSCAFP00000006021	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase.	0.818
EGFR	MET	ENSCAFP00000005164	ENSCAFP00000041478	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.989
EGFR	MST1R	ENSCAFP00000005164	ENSCAFP00000031338	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor.	0.810
EGFR	PTEN	ENSCAFP00000005164	ENSCAFP00000045099	Receptor protein-tyrosine kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]	0.892
FRK	BNIP2	ENSCAFP00000006021	ENSCAFP00000051399	Tyrosine-protein kinase.	BCL2 interacting protein 2.	0.840
FRK	E2RBZ7_CANLF	ENSCAFP00000006021	ENSCAFP00000017903	Tyrosine-protein kinase.	Uncharacterized protein.	0.765
FRK	EGFR	ENSCAFP00000006021	ENSCAFP00000005164	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.818
FRK	J9JHI0_CANLF	ENSCAFP00000006021	ENSCAFP00000035910	Tyrosine-protein kinase.	Uncharacterized protein.	0.679
FRK	KIAA1328	ENSCAFP00000006021	ENSCAFP00000026199	Tyrosine-protein kinase.	KIAA1328.	0.679
FRK	MET	ENSCAFP00000006021	ENSCAFP00000041478	Tyrosine-protein kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.656
FRK	MIPOL1	ENSCAFP00000006021	ENSCAFP00000059593	Tyrosine-protein kinase.	Mirror-image polydactyly 1.	0.967
FRK	MST1R	ENSCAFP00000006021	ENSCAFP00000031338	Tyrosine-protein kinase.	Macrophage stimulating 1 receptor.	0.928
FRK	PTEN	ENSCAFP00000006021	ENSCAFP00000045099	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]	0.922
FRK	SH2D1A	ENSCAFP00000006021	ENSCAFP00000041409	Tyrosine-protein kinase.	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	0.702
J9JHI0_CANLF	FRK	ENSCAFP00000035910	ENSCAFP00000006021	Uncharacterized protein.	Tyrosine-protein kinase.	0.679
J9JHI0_CANLF	KIAA1328	ENSCAFP00000035910	ENSCAFP00000026199	Uncharacterized protein.	KIAA1328.	0.900