POMC protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Score

POMC

Proopiomelanocortin. (264 aa)

Predicted Functional Partners:

MC4R

0.999

MC2R

0.999

MC3R

0.998

OPRM1

0.995

PDYN

0.982

MC5R

0.980

MRAP

0.976

OPRD1

0.975

PENK

0.972

LEP

0.964

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LEP	MC2R	ENSCAFP00000002433	ENSCAFP00000000251	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin 2 receptor.	0.568
LEP	MC3R	ENSCAFP00000002433	ENSCAFP00000043232	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin-3 receptor.	0.713
LEP	MC4R	ENSCAFP00000002433	ENSCAFP00000000126	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin-4 receptor.	0.919
LEP	MC5R	ENSCAFP00000002433	ENSCAFP00000000252	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Melanocortin 5 receptor.	0.451
LEP	POMC	ENSCAFP00000002433	ENSCAFP00000006163	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Proopiomelanocortin.	0.964
MC2R	LEP	ENSCAFP00000000251	ENSCAFP00000002433	Melanocortin 2 receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.568
MC2R	MC3R	ENSCAFP00000000251	ENSCAFP00000043232	Melanocortin 2 receptor.	Melanocortin-3 receptor.	0.882
MC2R	MC4R	ENSCAFP00000000251	ENSCAFP00000000126	Melanocortin 2 receptor.	Melanocortin-4 receptor.	0.886
MC2R	MC5R	ENSCAFP00000000251	ENSCAFP00000000252	Melanocortin 2 receptor.	Melanocortin 5 receptor.	0.587
MC2R	MRAP	ENSCAFP00000000251	ENSCAFP00000013046	Melanocortin 2 receptor.	Melanocortin 2 receptor accessory protein.	0.997
MC2R	POMC	ENSCAFP00000000251	ENSCAFP00000006163	Melanocortin 2 receptor.	Proopiomelanocortin.	0.999
MC3R	LEP	ENSCAFP00000043232	ENSCAFP00000002433	Melanocortin-3 receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.713
MC3R	MC2R	ENSCAFP00000043232	ENSCAFP00000000251	Melanocortin-3 receptor.	Melanocortin 2 receptor.	0.882
MC3R	MC4R	ENSCAFP00000043232	ENSCAFP00000000126	Melanocortin-3 receptor.	Melanocortin-4 receptor.	0.901
MC3R	MRAP	ENSCAFP00000043232	ENSCAFP00000013046	Melanocortin-3 receptor.	Melanocortin 2 receptor accessory protein.	0.748
MC3R	POMC	ENSCAFP00000043232	ENSCAFP00000006163	Melanocortin-3 receptor.	Proopiomelanocortin.	0.998
MC4R	LEP	ENSCAFP00000000126	ENSCAFP00000002433	Melanocortin-4 receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.919
MC4R	MC2R	ENSCAFP00000000126	ENSCAFP00000000251	Melanocortin-4 receptor.	Melanocortin 2 receptor.	0.886
MC4R	MC3R	ENSCAFP00000000126	ENSCAFP00000043232	Melanocortin-4 receptor.	Melanocortin-3 receptor.	0.901
MC4R	MC5R	ENSCAFP00000000126	ENSCAFP00000000252	Melanocortin-4 receptor.	Melanocortin 5 receptor.	0.773