MEIS3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

MEIS3

Meis homeobox 3. (424 aa)

Predicted Functional Partners:

METTL21C

0.682

MEIS2

0.625

MEIS1

0.625

PHOX2B

0.512

PBX2

0.477

HOXB1

0.474

ALG1

0.471

CD96

0.470

ADRA1B

0.467

PBX3

0.465

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRA1B	ALG1	ENSCAFP00000025460	ENSCAFP00000028202	Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Glycos_transf_1 domain-containing protein.	0.559
ADRA1B	CD96	ENSCAFP00000025460	ENSCAFP00000015242	Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	CD96 molecule.	0.576
ADRA1B	MEIS3	ENSCAFP00000025460	ENSCAFP00000006192	Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	Meis homeobox 3.	0.467
ALG1	ADRA1B	ENSCAFP00000028202	ENSCAFP00000025460	Glycos_transf_1 domain-containing protein.	Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	0.559
ALG1	CD96	ENSCAFP00000028202	ENSCAFP00000015242	Glycos_transf_1 domain-containing protein.	CD96 molecule.	0.577
ALG1	MEIS3	ENSCAFP00000028202	ENSCAFP00000006192	Glycos_transf_1 domain-containing protein.	Meis homeobox 3.	0.471
CD96	ADRA1B	ENSCAFP00000015242	ENSCAFP00000025460	CD96 molecule.	Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).	0.576
CD96	ALG1	ENSCAFP00000015242	ENSCAFP00000028202	CD96 molecule.	Glycos_transf_1 domain-containing protein.	0.577
CD96	MEIS3	ENSCAFP00000015242	ENSCAFP00000006192	CD96 molecule.	Meis homeobox 3.	0.470
HOXB1	MEIS2	ENSCAFP00000024764	ENSCAFP00000012556	Homeobox B1.	Meis homeobox 2.	0.694
HOXB1	MEIS3	ENSCAFP00000024764	ENSCAFP00000006192	Homeobox B1.	Meis homeobox 3.	0.474
HOXB1	PBX2	ENSCAFP00000024764	ENSCAFP00000001119	Homeobox B1.	PBX homeobox 2.	0.653
HOXB1	PBX3	ENSCAFP00000024764	ENSCAFP00000029917	Homeobox B1.	PBX homeobox 3.	0.653
MEIS1	MEIS3	ENSCAFP00000050012	ENSCAFP00000006192	Meis homeobox 1.	Meis homeobox 3.	0.625
MEIS1	PBX2	ENSCAFP00000050012	ENSCAFP00000001119	Meis homeobox 1.	PBX homeobox 2.	0.660
MEIS1	PBX3	ENSCAFP00000050012	ENSCAFP00000029917	Meis homeobox 1.	PBX homeobox 3.	0.689
MEIS2	HOXB1	ENSCAFP00000012556	ENSCAFP00000024764	Meis homeobox 2.	Homeobox B1.	0.694
MEIS2	MEIS3	ENSCAFP00000012556	ENSCAFP00000006192	Meis homeobox 2.	Meis homeobox 3.	0.625
MEIS2	PBX2	ENSCAFP00000012556	ENSCAFP00000001119	Meis homeobox 2.	PBX homeobox 2.	0.676
MEIS2	PBX3	ENSCAFP00000012556	ENSCAFP00000029917	Meis homeobox 2.	PBX homeobox 3.	0.591