C5AR1 protein (Canis lupus familiaris) - STRING interaction network

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C5AR1

C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity). (352 aa)

Predicted Functional Partners:

C5

0.989

VGF

0.875

SYK

0.825

C3

0.802

LOC484960

0.786

AP1S1

0.751

AP1S2

0.751

LOC481722

0.736

SRC

0.728

YES1

0.728

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP1S1	AP1S2	ENSCAFP00000022514	ENSCAFP00000057583	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.987
AP1S1	C5AR1	ENSCAFP00000022514	ENSCAFP00000006201	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.751
AP1S2	AP1S1	ENSCAFP00000057583	ENSCAFP00000022514	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.987
AP1S2	C5AR1	ENSCAFP00000057583	ENSCAFP00000006201	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.751
C3	C5	ENSCAFP00000027484	ENSCAFP00000005350	Complement C3.	Complement C5.	0.913
C3	C5AR1	ENSCAFP00000027484	ENSCAFP00000006201	Complement C3.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.802
C3	LOC481722	ENSCAFP00000027484	ENSCAFP00000042714	Complement C3.	Uncharacterized protein.	0.933
C5	C3	ENSCAFP00000005350	ENSCAFP00000027484	Complement C5.	Complement C3.	0.913
C5	C5AR1	ENSCAFP00000005350	ENSCAFP00000006201	Complement C5.	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	0.989
C5	LOC481722	ENSCAFP00000005350	ENSCAFP00000042714	Complement C5.	Uncharacterized protein.	0.713
C5	LOC484960	ENSCAFP00000005350	ENSCAFP00000026509	Complement C5.	Anaphylatoxin-like domain-containing protein.	0.713
C5AR1	AP1S1	ENSCAFP00000006201	ENSCAFP00000022514	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.751
C5AR1	AP1S2	ENSCAFP00000006201	ENSCAFP00000057583	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.751
C5AR1	C3	ENSCAFP00000006201	ENSCAFP00000027484	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	Complement C3.	0.802
C5AR1	C5	ENSCAFP00000006201	ENSCAFP00000005350	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	Complement C5.	0.989
C5AR1	LOC481722	ENSCAFP00000006201	ENSCAFP00000042714	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	Uncharacterized protein.	0.736
C5AR1	LOC484960	ENSCAFP00000006201	ENSCAFP00000026509	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	Anaphylatoxin-like domain-containing protein.	0.786
C5AR1	SRC	ENSCAFP00000006201	ENSCAFP00000044994	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	Tyrosine-protein kinase.	0.728
C5AR1	SYK	ENSCAFP00000006201	ENSCAFP00000054848	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	Tyrosine-protein kinase.	0.825
C5AR1	VGF	ENSCAFP00000006201	ENSCAFP00000020489	C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N- terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (By similarity).	VGF nerve growth factor inducible.	0.875

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