STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HEPHL1Hephaestin like 1; Belongs to the multicopper oxidase family. (1204 aa)    
Predicted Functional Partners:
KRT27
IF rod domain-containing protein; Belongs to the intermediate filament family.
   
  
 0.808
CHPF2
Hexosyltransferase.
      
 0.673
SNRPE
Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.
   
  
 0.603
POC1B
POC1 centriolar protein B.
      
 0.599
EPS8L3
EPS8 like 3.
   
  
 0.585
FGD6
FYVE, RhoGEF and PH domain containing 6.
      
 0.572
EDIL3
EGF like repeats and discoidin domains 3.
 
 
    0.566
C21H11orf54
Chromosome 21 C11orf54 homolog.
      
 0.536
MFGE8
Milk fat globule-EGF factor 8 protein.
 
 
    0.524
CEP295
Centrosomal protein 295.
      
 0.495
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.