STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C21H11orf54Chromosome 21 C11orf54 homolog. (315 aa)    
Predicted Functional Partners:
CEP295
Centrosomal protein 295.
 
    
 0.751
CCDC82
Coiled-coil domain containing 82.
      
 0.563
FRMD1
Uncharacterized protein.
      
 0.561
HEPHL1
Hephaestin like 1; Belongs to the multicopper oxidase family.
      
 0.536
NARS1
Asparaginyl-tRNA synthetase.
      
 0.515
HDLBP
High density lipoprotein binding protein.
      
 0.495
SGO2
Shugoshin 2.
      
 0.493
NFE2L1
Nuclear factor, erythroid 2 like 1.
      
 0.489
PLS1
Plastin 1.
      
 0.480
MED17
Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
 
    
 0.455
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.