ATP7B protein (Canis lupus familiaris) - STRING interaction network

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Score

ATP7B

ATPase copper transporting beta. (1434 aa)

Predicted Functional Partners:

COMMD1

0.958

CCS

0.958

ATOX1

0.944

LOC611632

0.893

CP

0.893

ATP7A

0.881

COX17

0.878

ATP6V0E1

0.777

SLC31A1

0.693

SOD1

0.689

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOX1	ATP6V0E1	ENSCAFP00000026329	ENSCAFP00000039612	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.809
ATOX1	ATP7A	ENSCAFP00000026329	ENSCAFP00000039150	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	ATPase copper transporting alpha.	0.985
ATOX1	ATP7B	ENSCAFP00000026329	ENSCAFP00000006351	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	ATPase copper transporting beta.	0.944
ATOX1	CCS	ENSCAFP00000026329	ENSCAFP00000042403	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.919
ATOX1	COMMD1	ENSCAFP00000026329	ENSCAFP00000004595	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...]	0.839
ATOX1	COX17	ENSCAFP00000026329	ENSCAFP00000016247	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).	0.942
ATOX1	CP	ENSCAFP00000026329	ENSCAFP00000046239	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	Ceruloplasmin; Belongs to the multicopper oxidase family.	0.812
ATOX1	LOC611632	ENSCAFP00000026329	ENSCAFP00000043372	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	Uncharacterized protein; Belongs to the multicopper oxidase family.	0.812
ATOX1	SLC31A1	ENSCAFP00000026329	ENSCAFP00000004778	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	Solute carrier family 31 member 1.	0.532
ATOX1	SOD1	ENSCAFP00000026329	ENSCAFP00000013012	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems.	0.728
ATP6V0E1	ATOX1	ENSCAFP00000039612	ENSCAFP00000026329	V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	0.809
ATP6V0E1	ATP7B	ENSCAFP00000039612	ENSCAFP00000006351	V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	ATPase copper transporting beta.	0.777
ATP7A	ATOX1	ENSCAFP00000039150	ENSCAFP00000026329	ATPase copper transporting alpha.	Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family.	0.985
ATP7A	ATP7B	ENSCAFP00000039150	ENSCAFP00000006351	ATPase copper transporting alpha.	ATPase copper transporting beta.	0.881
ATP7A	CCS	ENSCAFP00000039150	ENSCAFP00000042403	ATPase copper transporting alpha.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.974
ATP7A	COMMD1	ENSCAFP00000039150	ENSCAFP00000004595	ATPase copper transporting alpha.	COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...]	0.955
ATP7A	COX17	ENSCAFP00000039150	ENSCAFP00000016247	ATPase copper transporting alpha.	Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).	0.882
ATP7A	CP	ENSCAFP00000039150	ENSCAFP00000046239	ATPase copper transporting alpha.	Ceruloplasmin; Belongs to the multicopper oxidase family.	0.817
ATP7A	LOC611632	ENSCAFP00000039150	ENSCAFP00000043372	ATPase copper transporting alpha.	Uncharacterized protein; Belongs to the multicopper oxidase family.	0.817
ATP7A	SLC31A1	ENSCAFP00000039150	ENSCAFP00000004778	ATPase copper transporting alpha.	Solute carrier family 31 member 1.	0.748