STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LRRC17Leucine rich repeat containing 17. (463 aa)    
Predicted Functional Partners:
DIRAS1
DIRAS family GTPase 1.
    
 0.819
RARRES2
Retinoic acid receptor responder 2.
      
 0.726
CREB3L1
cAMP responsive element binding protein 3 like 1.
      
 0.698
INSR
Tyrosine-protein kinase receptor.
    
 0.662
SESTD1
SEC14 and spectrin domain containing 1.
      
 0.620
PCOLCE2
Procollagen C-endopeptidase enhancer 2.
   
  
 0.605
DACT1
Dishevelled binding antagonist of beta catenin 1.
      
 0.592
DPRX
Divergent-paired related homeobox.
    
 
 0.570
CRX
Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity); Belongs to the paired homeobox family.
      
 0.566
SOX3
SRY-box 3.
    
 
 0.559
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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