F1PIN6_CANLF protein (Canis lupus familiaris)

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F1PIN6_CANLF

Uncharacterized protein; Belongs to the calmodulin family. (364 aa)

Predicted Functional Partners:

PRKACA

0.934

PRKACB

0.929

RYR2

0.909

NOS3

0.865

PDE1A

0.829

CAMKK2

0.826

RYR1

0.817

PDE1B

0.817

PDE1C

0.813

CASQ1

0.785

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAMKK2	F1PIN6_CANLF	ENSCAFP00000012271	ENSCAFP00000006379	Calcium/calmodulin dependent protein kinase kinase 2.	Uncharacterized protein; Belongs to the calmodulin family.	0.826
CASQ1	F1PIN6_CANLF	ENSCAFP00000040392	ENSCAFP00000006379	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Uncharacterized protein; Belongs to the calmodulin family.	0.785
CASQ1	PRKACA	ENSCAFP00000040392	ENSCAFP00000053880	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.643
CASQ1	PRKACB	ENSCAFP00000040392	ENSCAFP00000030135	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.643
CASQ1	RYR1	ENSCAFP00000040392	ENSCAFP00000008828	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 1.	0.972
CASQ1	RYR2	ENSCAFP00000040392	ENSCAFP00000014764	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	Ryanodine receptor 2.	0.985
F1PIN6_CANLF	CAMKK2	ENSCAFP00000006379	ENSCAFP00000012271	Uncharacterized protein; Belongs to the calmodulin family.	Calcium/calmodulin dependent protein kinase kinase 2.	0.826
F1PIN6_CANLF	CASQ1	ENSCAFP00000006379	ENSCAFP00000040392	Uncharacterized protein; Belongs to the calmodulin family.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.785
F1PIN6_CANLF	NOS3	ENSCAFP00000006379	ENSCAFP00000061234	Uncharacterized protein; Belongs to the calmodulin family.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family.	0.865
F1PIN6_CANLF	PDE1A	ENSCAFP00000006379	ENSCAFP00000031635	Uncharacterized protein; Belongs to the calmodulin family.	Phosphodiesterase.	0.829
F1PIN6_CANLF	PDE1B	ENSCAFP00000006379	ENSCAFP00000038470	Uncharacterized protein; Belongs to the calmodulin family.	Phosphodiesterase.	0.817
F1PIN6_CANLF	PDE1C	ENSCAFP00000006379	ENSCAFP00000053961	Uncharacterized protein; Belongs to the calmodulin family.	Phosphodiesterase.	0.813
F1PIN6_CANLF	PRKACA	ENSCAFP00000006379	ENSCAFP00000053880	Uncharacterized protein; Belongs to the calmodulin family.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.934
F1PIN6_CANLF	PRKACB	ENSCAFP00000006379	ENSCAFP00000030135	Uncharacterized protein; Belongs to the calmodulin family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.929
F1PIN6_CANLF	RYR1	ENSCAFP00000006379	ENSCAFP00000008828	Uncharacterized protein; Belongs to the calmodulin family.	Ryanodine receptor 1.	0.817
F1PIN6_CANLF	RYR2	ENSCAFP00000006379	ENSCAFP00000014764	Uncharacterized protein; Belongs to the calmodulin family.	Ryanodine receptor 2.	0.909
NOS3	F1PIN6_CANLF	ENSCAFP00000061234	ENSCAFP00000006379	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family.	Uncharacterized protein; Belongs to the calmodulin family.	0.865
NOS3	PRKACA	ENSCAFP00000061234	ENSCAFP00000053880	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.413
NOS3	PRKACB	ENSCAFP00000061234	ENSCAFP00000030135	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.410
NOS3	RYR1	ENSCAFP00000061234	ENSCAFP00000008828	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family.	Ryanodine receptor 1.	0.551