GSAP protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GSAP

Gamma-secretase activating protein. (795 aa)

Predicted Functional Partners:

TPPP

0.751

CNTNAP1

0.657

APH1B

0.639

NEURL1B

0.621

NCSTN

0.619

ENPP7

0.602

APP

0.568

CREB5

0.564

SPON1

0.561

PSENEN

0.546

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH1B	APP	ENSCAFP00000037055	ENSCAFP00000012583	Aph-1 homolog B, gamma-secretase subunit.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.711
APH1B	CNTNAP1	ENSCAFP00000037055	ENSCAFP00000048282	Aph-1 homolog B, gamma-secretase subunit.	Contactin associated protein 1.	0.577
APH1B	GSAP	ENSCAFP00000037055	ENSCAFP00000006410	Aph-1 homolog B, gamma-secretase subunit.	Gamma-secretase activating protein.	0.639
APH1B	NCSTN	ENSCAFP00000037055	ENSCAFP00000065126	Aph-1 homolog B, gamma-secretase subunit.	Ncstrn_small domain-containing protein.	0.994
APH1B	PSENEN	ENSCAFP00000037055	ENSCAFP00000039072	Aph-1 homolog B, gamma-secretase subunit.	Presenilin enhancer, gamma-secretase subunit.	0.995
APH1B	TPPP	ENSCAFP00000037055	ENSCAFP00000038343	Aph-1 homolog B, gamma-secretase subunit.	Tubulin polymerization promoting protein.	0.686
APP	APH1B	ENSCAFP00000012583	ENSCAFP00000037055	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Aph-1 homolog B, gamma-secretase subunit.	0.711
APP	GSAP	ENSCAFP00000012583	ENSCAFP00000006410	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Gamma-secretase activating protein.	0.568
APP	NCSTN	ENSCAFP00000012583	ENSCAFP00000065126	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Ncstrn_small domain-containing protein.	0.975
APP	PSENEN	ENSCAFP00000012583	ENSCAFP00000039072	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Presenilin enhancer, gamma-secretase subunit.	0.891
APP	SPON1	ENSCAFP00000012583	ENSCAFP00000012337	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Spondin 1.	0.606
CNTNAP1	APH1B	ENSCAFP00000048282	ENSCAFP00000037055	Contactin associated protein 1.	Aph-1 homolog B, gamma-secretase subunit.	0.577
CNTNAP1	GSAP	ENSCAFP00000048282	ENSCAFP00000006410	Contactin associated protein 1.	Gamma-secretase activating protein.	0.657
CNTNAP1	TPPP	ENSCAFP00000048282	ENSCAFP00000038343	Contactin associated protein 1.	Tubulin polymerization promoting protein.	0.650
CREB5	ENPP7	ENSCAFP00000060664	ENSCAFP00000057622	cAMP responsive element binding protein 5.	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	0.575
CREB5	GSAP	ENSCAFP00000060664	ENSCAFP00000006410	cAMP responsive element binding protein 5.	Gamma-secretase activating protein.	0.564
CREB5	SPON1	ENSCAFP00000060664	ENSCAFP00000012337	cAMP responsive element binding protein 5.	Spondin 1.	0.512
ENPP7	CREB5	ENSCAFP00000057622	ENSCAFP00000060664	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	cAMP responsive element binding protein 5.	0.575
ENPP7	GSAP	ENSCAFP00000057622	ENSCAFP00000006410	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	Gamma-secretase activating protein.	0.602
ENPP7	SPON1	ENSCAFP00000057622	ENSCAFP00000012337	Ectonucleotide pyrophosphatase/phosphodiesterase 7.	Spondin 1.	0.561